ISSN 1674-3865  CN 21-1569/R
主管：国家卫生健康委员会
主办：中国医师协会
　　　辽宁省基础医学研究所
　　　辽宁中医药大学附属医院
中国中西医结合儿科学

中国中西医结合儿科学 ›› 2019, Vol. 11 ›› Issue (3): 198-201.doi: 10.3969/j.issn.1674-3865.2019.03.005

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女性癫痫患者青春期发作频率变化及其影响因素研究

陈海鹏，马融   

  1. 100078 北京，北京中医药大学东方医院儿科（陈海鹏）；300381 天津，天津中医药大学第一附属医院（马融）
  • 收稿日期:2019-06-10 出版日期:2019-06-25 上线日期:2019-06-25
  • 通讯作者: 马融，E-mail：mr1974@163.com
  • 作者简介:陈海鹏（1988-），男，医学博士，医师。研究方向：中医药治疗脑系疾病
  • 基金资助:
    国家自然科学基金面上项目（81574018）

Study on the change of seizure frequency and the related risk factors during adolescence in women with epilepsy

CHEN Haipeng，MA Rong   

  1. Oriental Hospital of Beijing University of Traditional Chinese Medicine，Beijing 100078，China
  • Received:2019-06-10 Published:2019-06-25 Online:2019-06-25
  • Contact: MA Rong，E-mail：mr1974@163.com

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摘要： 目的:探讨女性癫痫患者青春期是否加重、加重比例，发作加重的影响因素。方法:采用回顾性研究方法，共筛选符合纳入排除标准女性癫痫患者101例，将其分为加重组和无加重组，收集其一般资料、发作情况资料、药物使用资料、发作控制评价资料。结果:发作频率无增加者占83.17%（84/101）；发作频率增加者占16.83%（17/101）。其中69.31%（70/101）患者进入青春期无发作。无加重组疗后脑电图、发作类型、总体用药与加重组比较，差异有统计学意义（P<0.05）。Logistic回归分析结果显示：疗后脑电图、发作类型、总体用药成为发作频率是否加重的影响因素进入方程。结论:多数女性癫痫患者进入青春期发作无加重，其中多数患者无发作；青春期女性癫痫患者疗后脑电图异常者、局灶性发作者可能更易出现发作加重；中西药联合者易表现为发作加重。

关键词: 癫痫, 青春期, 发作频率, 影响因素, 女性

Abstract: Objective:To study whether there is aggravation during adolescence, the proportion of aggravation and related risk factors in epileptic women.Methods:With the method of retrospective study, a total of 101 female epilepsy patients who met the inclusion-exclusion criteria were screened and divided into aggravation group and no-aggravation group. General data, seizure information, drug use data and seizure control evaluation data were collected.Results:In the 101 women 84 had no change in the seizure frequency, accounting for 83.17%(84/101). In 17 cases the frequency of seizures increased, accounting for 16.83%(17/101). About 69.31% of the patients had no seizures when they grew into puberty. There was statistically significant difference in EEG after treatment, seizure type and general medication between the group of aggravation and the group of no-aggravation(P＜0.05). The results of multivariate Logistic regression analysis showed that the factors affecting the seizure frequency were EEG after treatment, seizure type and general medication.Conclusion:In most adolescent women with epilepsy，the onset of the disease becomes less frequent or they are seizure free. The patients with abnormal EEG after treatment and focal seizures are more prone to aggravate. The patients receiving traditional Chinese medicine combined with western medicine are more likely to have aggravation.

Key words: Epilepsy, Puberty, Seizure frequency, Related risk factors, Woman