ISSN 1674-3865  CN 21-1569/R
主管:国家卫生健康委员会
主办:中国医师协会
   辽宁省基础医学研究所
   辽宁中医药大学附属医院

中国中西医结合儿科学 ›› 2025, Vol. 17 ›› Issue (2): 132-136.doi: 10.20274/j.cnki.issn.1674-3865.2025.02.007

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神经递质失衡在抽动障碍中的研究进展

姜玲, 张迪, 刘英   

  1. 330004 南昌,江西中医药大学临床医学院2022级中医儿科学专业研究生(姜玲);江西中医药大学附属医院儿科(张迪,刘英)

  • 收稿日期:2024-07-12 出版日期:2025-04-25 上线日期:2025-04-25
  • 通讯作者: 刘英,E-mail:595317906@qq.com

Research progress of neurotransmitter imbalance in tic disorders

JIANG Ling1,ZHANG Di2,LlU Ying2   

  1. 1Jiangxi University of Traditional Chinese Medicine,Nanchang 330004,China;2Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine,Nanchang 330004,China

  • Received:2024-07-12 Published:2025-04-25 Online:2025-04-25
  • Contact: LlU Ying,E-mail:595317906@qq.com
  • Supported by:
    江西省中医药管理局科技计划项目(2023B1239);江西省教育厅科学技术研究项目(GJJ2200983);江西省中医药管理局科技计划项目(2022B509);江西省卫生健康委科技计划项目(202310696)

摘要: 抽动障碍是一种神经精神障碍性疾病,其病因和发病机制尚未完全明确,近年来患病率呈现上升趋势。抽动障碍患者常常伴随着注意缺陷多动障碍、强迫症、学习困难、焦虑和抑郁等合并症,这些问题不仅对儿童的学业产生负面影响,还可能对他们的生长发育和心理健康带来严重困扰。研究表明,抽动障碍的发生与神经递质失衡、遗传因素、社会心理因素以及感染免疫因素等多种因素密切相关。神经递质在维持正常神经系统功能方面发挥着至关重要的作用,而抽动障碍患者的神经递质可能存在失衡,从而影响他们的行为和认知功能。深入研究抽动障碍的发病机制,尤其神经递质失衡方面的研究,有助于我们更好地理解其病理过程,也为控制其症状提供了新的治疗思路和策略。通过针对性的治疗和干预,可以有效地缓解症状,帮助患者改善生活质量,减少其对社会和家庭的负面影响。本文重点综述了神经递质失衡与抽动障碍发病的关系。


关键词: 抽动障碍, 发病机制, 神经递质失衡, 儿童

Abstract: Tic disorder(TD) is a neuropsychiatric disorder,the exact causes and mechanisms of which are not yet fully understood.In recent years,the prevalence of tic disorder has been on the rise.Patients with TD often present with comorbidities such as attention deficit hyperactivity disorder,obsessive compulsive disorder,learning difficulties,anxiety,and depression.These issues not only negatively impact children's academic performance but may also bring great trouble to their growth,development,and mental health.Researches have indicated that the occurrence of TD is closely related to various factors,including neurotransmitter imbalance,genetic factors,psychosocial factors,and infections or immune factors.Neurotransmitters play a crucial role in maintaining normal function of nervous system,and in TD patients,there may be neurotransmitter imbalance,which affects their behavior and cognitive functions.In depth research in the pathogenesis of TD,especially in neurotransmitter imbalance,helps us better understand its pathological processes and provides new therapeutic approaches and strategies for controlling its symptoms.Through targeted treatment and interventions,symptoms can be effectively alleviated,which helps patients improve their quality of life and reduce the negative impact on society and families.This article mainly reviews the relationship between neurotransmitter imbalance and the development of tic disorder.

Key words: Tic disorders, Pathogenesis, Neurotransmitter imbalance, Child