ISSN 1674-3865  CN 21-1569/R
主管：国家卫生健康委员会
主办：中国医师协会
　　　辽宁省基础医学研究所
　　　辽宁中医药大学附属医院
中国中西医结合儿科学

中国中西医结合儿科学 ›› 2017, Vol. 9 ›› Issue (2): 103-105.doi: 10.3969/j.issn.1674-3865.2017.02.004

• 临床论著 • 上一篇    下一篇

微创埋线对小儿咳嗽变异性哮喘血清免疫球蛋白及血小板活化因子的影响

金继超   

  1. 457000郑州，郑州市中医院儿科
  • 出版日期:2017-04-25 上线日期:2017-12-18
  • 通讯作者: 金继超(1984-)，男，医学硕士，医师。研究方向：中医药治疗小儿呼吸系统疾病，E-mail：jinjichao8@163.com
  • 作者简介:金继超(1984-)，男，医学硕士，医师。研究方向：中医药治疗小儿呼吸系统疾病，E-mail：jinjichao8@163.com
  • 基金资助:
    郑州市科技局2013年科技领军人才项目(131PLJRC672)

Influence of minimally invasive embedder wire on serum immunoglobulin and plate activating factor of children with cough variant asthma

JIN Jichao   

  1. Pediatric Department of Zhengzhou TCM Hospital, Zhengzhou 457000, China
  • Published:2017-04-25 Online:2017-12-18

PDF (PC)

290

摘要：
目的：研究微创埋线对咳嗽变异性哮喘患儿血清IgE、IgG、IgA及血小板活化因子（PAF）的影响。
方法：2013年3月至2015年12月郑州市中医院、郑州市儿童医院、河南中医学院第三附属医院儿科门诊收治CVA患儿206例，随机分为观察组101例和对照组105例。观察组微创埋线联合口服孟鲁司特钠咀嚼片，对照组口服孟鲁司特钠咀嚼片。两组疗程均为3个月。观察治疗前后临床疗效及治疗前后血清IgE、IgG、IgA及PAF的变化。
结果：观察组总有效率为93.1％（94/101），对照组为87.6％（92/105），差异有统计学意义（P＜0.05）。观察组治疗后血清总IgE、IgG、IgA、PAF水平的改善情况优于对照组，差异有统计学意义（P＜0.05）。
结论：微创埋线可以提高IgA、IgG水平，提高患儿免疫力；可抑制PAF的过度释放控制炎症反应水平；可有效降低IgE介导的过敏反应，减少气道变态反应性炎症。

关键词: 咳嗽变异性哮喘, 微创埋线, 儿童

Abstract:
Objective：To study the influence of minimally invasive embedded wire on serum IgE, IgG, IgA and PAF of children with cough variant asthma.
Methods：A total of 206 children with CVA who received treatment from Mar. 2013 to Dec.2015 were randomly divided into observation group(101 children) and control group(105 children). The observation group was treated with minimally invasive embedded wire and montelukast chewable tablets, while the control group only took montelukast chewable tablets. The treatment course was 3 months for both groups. Observe the clinical effect and the changes of IgE, IgG, IgA and PAF after treatment.
Results：The total effective rate of the observation group was 93.1%(94/101) and it was 87.6%(92/105) in the control group, the difference between them was of statistical significance(P<0.05).The improvement in serum level of total IgE,IgG,IgA and PAF was better in the observation group after treatment, and there was statistical difference(P<0.05).
Conclusion：Minimally invasive embedded wire can increase the level of IgA and IgG and the children's immunity.It can inhibit the excessive release of PAF and control inflammation level. It effectively reduce IgE-mediated allergic reaction and airway allergic inflammation.

Key words: Cough variant asthma, Minimally invasive embedded wire, Children