ISSN 1674-3865  CN 21-1569/R
主管：国家卫生健康委员会
主办：中国医师协会
　　　辽宁省基础医学研究所
　　　辽宁中医药大学附属医院
中国中西医结合儿科学

中国中西医结合儿科学 ›› 2021, Vol. 13 ›› Issue (1): 72-.

• 临床研究 • 上一篇    下一篇

早期新生儿骨代谢指标血清水平分析

宿军，付扬喜   

  1. 519020 广东 珠海，珠海市中西医结合医院（珠海市第二人民医院）新生儿科（宿军）；725000 陕西 安康，安康市中心医院新生儿科（付扬喜）
  • 出版日期:2021-02-25 发布日期:2021-05-17
  • 通讯作者: 宿军，E-mail:306202113@qq.com
  • 作者简介:宿军（1971-），男，医学硕士，副主任医师。研究方向：新生儿骨代谢
  • 基金资助:
    珠海市科技计划医疗卫生项目（20181117E030039）

Analysis of serum levels of early neonatal bone metabolism indexes

SU Jun，FU Yangxi.   

  1. Department of Neonatology, Zhuhai Hospital of Integrated Traditional Chinese and Western Medicine（The Second People’s Hospital of Zhuhai）, Zhuhai 519020,China
  • Online:2021-02-25 Published:2021-05-17

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摘要： 目的：分析早期新生儿骨代谢指标血清值水平。
方法：采集2018年7月至2019年12月在我院新生儿科住院的早期新生儿121例，检测血清骨代谢指标总碱性磷酸酶（ALP）、总Ⅰ型前胶原N端前肽（PINP）、β-Ⅰ型胶原交联羧基端肽区(β-CTX)、钙、磷、25-羟胆骨化醇（25-（OH）D）、甲状旁腺激素、降钙素的浓度，进行血清水平分析。
结果：（1）新生儿血清PINP检测结果均>1 200.00 μg/L，111例（91.74%）存在维生素D缺乏或者不足。（2）早产儿甲状旁腺激素水平高于足月儿，降钙素水平低于足月儿，差异有统计学意义（P<0.05）。早产儿和足月儿其他骨代谢指标比较差异无统计学意义（P>0.05）。（3）血清骨代谢指标水平与母亲年龄及胎龄无相关性，β-CTX与头围负相关，钙与体质量和头围正相关，甲状旁腺激素与体质量和身长负相关，降钙素与体质量正相关。
结论：（1）维生素D缺乏或不足发生率高，需要加强孕期母亲规律补充维生素D制剂；（2）新生儿甲状旁腺激素、降钙素血清水平与胎龄有关，早产儿甲状旁腺激素高于足月儿，降钙素低于足月儿；（3）新生儿骨代谢指标血清水平与体质量、头围、身长相关。

关键词: 骨代谢标志物, 25-羟胆骨化醇, 甲状旁腺激素, 降钙素, 婴儿, 新生

Abstract: Objective：To analyze the serum levels of bone metabolism indexes in early neonates.
Methods：A total of 121 early neonates who were admitted to the neonatal department of our hospital from July 2018 to December 2019 were included. The concentration of serum indexes of bone metabolism was determined, including ALP, PINP, β-CTX, Ca, P, 25-(OH)D, PTH and CT, and the serum levels were analyzed.
Results：(1) The serum PINP levels were all more than 1 200.00 μg/L, and 111 cases (91.74%) had lack or deficiency of vitamin D. (2) The level of PTH was higher in preterm infants than in term infants, while CT level was lower, and the difference was statistically significant(P<0.05). There was no difference in the other bone metabolism indexes between the preterm infants and term infants(P>0.05). (3) There was no correlation between serum levels of bone metabolism indexes and maternal age or gestational age. The β-CTX was negatively correlated with head circumference; Ca was positively correlated with body weight and head circumference; PTH was negatively correlated with body weight and body length; CT was positively correlated with body weight.
Conclusion：(1)The incidence of lack of vitamin D or deficiency is high, and it is necessary to strengthen the regular supplementation of vitamin D in pregnant mothers. (2)The serum levels of PTH and CT in newborns are related to gestational age. The serum level of PTH in the preterm infants was higher than that in term infants, while the CT level was lower. (3)Serum levels of newborn bone metabolism indexes are related to body weight, head circumference, and length.

Key words: Bone metabolism marker, 25hydroxycholesterol, Parathyroid hormone, Calcitonin, Newborn