ISSN 1674-3865  CN 21-1569/R
主管：国家卫生健康委员会
主办：中国医师协会
　　　辽宁省基础医学研究所
　　　辽宁中医药大学附属医院
中国中西医结合儿科学

中国中西医结合儿科学 ›› 2021, Vol. 13 ›› Issue (1): 76-.

• 小儿中药应用研究 • 上一篇    下一篇

加味清心莲子饮治疗肾病综合征激素撤减期临床研究

王海, 武明月，张永政   

  1. 150040 哈尔滨，黑龙江中医药大学附属第一医院儿科二科（王海，张永政）；黑龙江中医药大学第一临床医学院2018级中医儿科学专业研究生（武明月）
  • 出版日期:2021-02-25 发布日期:2021-05-17
  • 通讯作者: 王海，E-mail：782955547@qq.com
  • 作者简介:王海（1972-），男，医学博士，主任医师。研究方向：中西医结合治疗小儿肾脏疾病
  • 基金资助:
    黑龙江省中医药科研项目（2018-ZHY18-062）

Clinical study of Jiawei Qingxin Lianzi decoction in the treatment of nephrotic syndrome during hormone withdrawal period

WANG Hai, WU Mingyue, ZHANG Yongzheng.   

  1. The First Affiliated Hospital of Heilongjiang University of Traditional Chinese Medicine，Harbin 150040，China
  • Online:2021-02-25 Published:2021-05-17

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摘要： 目的:观察加味清心莲子饮对肾病综合征激素撤减期减毒增效的作用。
方法:选取2018年3月至2019年3月黑龙江中医药大学附属第一医院儿科二科门诊收治的单纯性肾病综合征激素撤减期患儿70例，随机分为观察组和对照组各35例。在常规激素减量治疗基础上，对照组予槐杞黄颗粒治疗，观察组予加味清心莲子饮汤剂，疗程均为8周。对比两组患儿治疗前后中医证候积分、副反应、身高增长情况及治疗后复发情况。
结果:观察组脱落3例，对照组脱落5例。治疗后观察组中医证候积分、复发率及副反应发生率较对照组降低，差异有统计学意义（P<0.05）；观察组治疗总有效率为90.6%（29/32）,高于对照组60.0%(18/30)，差异有统计学意义（P<0.05）；观察组患儿身高增量高于对照组，差异有统计学意义（P<0.05）。
结论:加味清心莲子饮对激素治疗肾病综合症有增效减毒作用，且降低复发率，改善患儿预后。

关键词: 肾病综合征, 糖皮质激素, 气阴两虚, 加味清心莲子饮, 减毒增效

Abstract: Objective:To observe the effect of Jiawei Qingxin Lianzi decoction on nephrotic syndrome during hormone withdrawal.
Methods:From March 2018 to March 2019, 70 children with simple nephrotic syndrome were treated the Second Outpatient Department of the First Affiliated Hospital of Heilongjiang University of Traditional Chinese Medicine, and they were randomly divided into two groups. On the basis of conventional hormone therapy, 35 cases in the control group were treated with Huaiqihuang granules, and 35 cases in the experimental group were given Jiawei Qingxin Lianzi decoction, the course of treatment being 8 weeks. The TCM symptom scores, side effects and height growth were compared between the two groups before and after treatment, and the relapse after treatment was also compared.
Results:There were 3 cases who were lost of follow-up in experimental group and 5 cases in the control group. After treatment, the TCM symptom score, recurrence rate and incidence of side effects in the experimental group were lower than those in the control group, and the difference was statistically significant(P<0.05); the total effective rate in experimental group was 90.6%(29/32), which was higher than that in control group(60.0%, 18/30)(P<0.05); the increase in height of the children in the experimental group was higher than that in the control group, and the difference was statistically significant(P<0.05).
Conclusion:Jiawei Qingxin Lianzi decoction has a synergistic and detoxifying effect on hormone treatment for nephrotic syndrome, and reduces the recurrence rate and improves the prognosis of children.

Key words: Nephrotic syndrome, Glucocorticoid, Deficiency of both Qi and Yin, Jiawei Qingxin Lianzi decoction, Detoxification and synergism