ISSN 1674-3865  CN 21-1569/R
主管：国家卫生健康委员会
主办：中国医师协会
　　　辽宁省基础医学研究所
　　　辽宁中医药大学附属医院
中国中西医结合儿科学

中国中西医结合儿科学 ›› 2021, Vol. 13 ›› Issue (3): 237-240.

• 临床研究 • 上一篇    下一篇

中医辨证治疗小儿紫癜性肾炎的疗效与分析

目的: 探讨中医辨证治疗小儿紫癜性肾炎的临床疗效。
方法: 选择2017年9月至2019年6月我院收治住院的HSPN患儿62例为研究对象，随机分为对照组和观察组各31例。对照组采用常规西药治疗，观察组在对照组基础上采用中医辨证方加减治疗，两组患儿均连续治疗20周；比较两组患儿临床疗效以及治疗前后24 h尿蛋白定量及尿红细胞计数的变化。
结果: 治疗20周后，观察组总有效率为96.8%（30/31），明显高于对照组74.2%（23/31），差异有统计学意义（P<0.05）。观察组24 h尿蛋白定量、尿红细胞计数显著低于对照组，差异有统计学意义（P<0.05）。观察组不良反应发生率明显低   

  1. 475000 河南 开封，开封市儿童医院儿科
  • 出版日期:2021-06-25 发布日期:2021-12-17
  • 通讯作者: 张莉 ，E-mail:365068585@qq.com
  • 作者简介:张莉（1986-），女，医学硕士，医师。研究方向：中西医结合防治小儿肾脏疾病

Therapeutic effect and analysis of syndrome-differentiated treatment for children with Henoch-Schonlein purpuranephritis with traditional Chinese medicine

Objective: To explore the clinical effect of syndrome-differentiated treatment for children with Henoch-Schonlein purpura nephritis（HSPN） with traditional Chinese medicine.#br# Methods: A total of 62 childrenwith HSPN admitted to our hospital from September 2017 to June 2019 were selected as the research subjects, and they were randomly divided into control group and observation group, with 31 cases in each group. The control group was treated with conventional western medicine, and the observation group received modified TCM treatment based on syndrome differentiation as well as western medicine. Patients in both groups were treated for 20 weeks continuously. The clinical efficacy and the changes in urinary protein and erythrocyte count in 24 h before and after treatment were compared between the two groups.#br# Results: After 20 weeks of treatment, the total effective rate of the observation group was 96.8% (30/31), which was significantly higher than that of the control group(74.2%,23/31), and the difference was statistically significant(P<0.05). The 24 h urine protein quantity and urine red blood cell count in the observation group were significantly lower than those in the control group, and the differences were statistically significant (P<0.05). The incidence of adverse reactions in the observation group was significantly lower than that in the control group, and the difference was statistically significant(P<0.05).#br# Conclusion: The treatment with TCM based on syndrome differentiation has significant curative effect and can prevent kidney damage, which is worthy of clinical promotion.   

  1. Children's Hospital of Kaifeng, Kaifeng 475000,China
  • Online:2021-06-25 Published:2021-12-17

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摘要： 目的: 探讨中医辨证治疗小儿紫癜性肾炎的临床疗效。
方法: 选择2017年9月至2019年6月我院收治住院的HSPN患儿62例为研究对象，随机分为对照组和观察组各31例。对照组采用常规西药治疗，观察组在对照组基础上采用中医辨证方加减治疗，两组患儿均连续治疗20周；比较两组患儿临床疗效以及治疗前后24 h尿蛋白定量及尿红细胞计数的变化。
结果: 治疗20周后，观察组总有效率为96.8%（30/31），明显高于对照组74.2%（23/31），差异有统计学意义（P<0.05）。观察组24 h尿蛋白定量、尿红细胞计数显著低于对照组，差异有统计学意义（P<0.05）。观察组不良反应发生率明显低

关键词: 过敏性紫癜, 肾损害, 中医辨证, 儿童

Abstract: Objective: To explore the clinical effect of syndrome-differentiated treatment for children with Henoch-Schonlein purpura nephritis（HSPN） with traditional Chinese medicine.
Methods: A total of 62 childrenwith HSPN admitted to our hospital from September 2017 to June 2019 were selected as the research subjects, and they were randomly divided into control group and observation group, with 31 cases in each group. The control group was treated with conventional western medicine, and the observation group received modified TCM treatment based on syndrome differentiation as well as western medicine. Patients in both groups were treated for 20 weeks continuously. The clinical efficacy and the changes in urinary protein and erythrocyte count in 24 h before and after treatment were compared between the two groups.
Results: After 20 weeks of treatment, the total effective rate of the observation group was 96.8% (30/31), which was significantly higher than that of the control group(74.2%,23/31), and the difference was statistically significant(P<0.05). The 24 h urine protein quantity and urine red blood cell count in the observation group were significantly lower than those in the control group, and the differences were statistically significant (P<0.05). The incidence of adverse reactions in the observation group was significantly lower than that in the control group, and the difference was statistically significant(P<0.05).
Conclusion: The treatment with TCM based on syndrome differentiation has significant curative effect and can prevent kidney damage, which is worthy of clinical promotion.

Key words: Henoch-Schonlein purpura, Kidney damage, Traditional Chinese medicine based on syndrome differentiation, Children