极低出生体重儿视网膜病变风险因素分析

doi:10.20274/j.cnki.issn.1674-3865.2025.03.011

Abstract

Abstract:

Objective To explore the prevalence and risk factors of retinopathy of prematurity(ROP) in very low birth weight infants. Method A retrospective analysis was conducted on 242 extremely low birth weight infants admitted to Hunan Children's Hospital from January 2021 to March 2024. They were divided into ROP group(71 cases) and non?ROP group(171 cases) based on whether ROP occurred. Single factor analysis was conducted based on patient general information questionnaire, maternal perinatal status, and related diseases of premature infants, and single factors with statistical significance were selected for Logistic regression analysis. Result The detection rate of ROP in 242 children was 29.34% (71/242). Univariate analysis showed that there were significant differences in maternal hypertension and diabetes mellitus, vaginal delivery, multiple births, in vitro fertilization, birth weight, intrauterine infection, mechanical ventilation, oxygen inhalation time >5 days and blood transfusion treatment between the two groups (P<0.05). Logistic regression analysis showed that maternal diabetes mellitus, intrauterine infection, blood transfusion therapy, and oxygen inhalation time >5 days during pregnancy were independent risk factors for the development of ROP. Conclusion The detection rate of ROP in very low birth weight infants is high, and maternal diabetes mellitus, intrauterine infection, blood transfusion therapy, and oxygen inhalation time >5 days during pregnancy are independent risk factors for ROP in very low birth weight infants. Regular fundus screening and prompt treatment are essential to preventing vision loss and even blindness caused by ROP.

Key words: Retinopathy, Risk factors, Very low birth weight infants, Child

CLC Number:

R774.1

Huishuang CHEN, Qingling GUO, Lu DAI. Analysis of risk factors for retinopathy in very low birth weight infants[J]. Chinese Pediatrics of Integrated Traditional and Western Medicine, 2025, 17(3): 246-250.

Figures/Tables 3

Table 1

Table 2

Table 3

References 16

[1]	刘选成, 谷名晓, 单若冰, 等. 极低出生体重儿支气管肺发育不良并发肺动脉高压的影响因素[J]. 山东医药, 2024, 64(4): 77-80.
[2]	鲁玉姣, 高喜容, 庄严, 等. 长疗程使用枸橼酸咖啡因对极低出生体重儿安全性的影响[J]. 中国中西医结合儿科学, 2023, 15(2): 105-109.
[3]	朱莎, 许静, 石然然, 等. 极低出生体重儿先天性甲状腺功能减低症与住院期间不良结局的关系[J]. 中华儿科杂志, 2024, 62(1): 29-35.
[4]	刘秋彤, 吴艳, 宋思捷, 等. 极低出生体重早产儿视网膜病变的相关危险因素及近期转归[J]. 眼科新进展, 2021, 41(8): 745-749.
[5]	中华医学会儿科学分会眼科学组. 早产儿视网膜病变治疗规范专家共识[J]. 中华眼底病杂志, 2022, 38(1): 10-13.
[6]	王毅, 吴斯琪, 肖亦爽. 早产儿视网膜病变危险因素研究新进展[J]. 中国斜视与小儿眼科杂志, 2022, 30(3): 47-48.
[7]	中华医学会眼科学分会眼底病学组. 中国早产儿视网膜病变筛查指南(2014年)[J]. 中华眼科杂志, 2014, 50(12): 933-935.
[8]	赵翠. 早产儿视网膜病变患儿致病危险因素及不同分期发病率的探究[J]. 黑龙江医学, 2023, 47(4): 396-399.
[9]	阮钰, 王俊豪, 金芬品. 催产素引产时间对足月妊娠期高血压和轻度子痫前期孕妇妊娠结局的影响[J]. 吉林医学, 2024, 45(2): 269-272.
[10]	唐稳稳, 马清敏, 李科军, 等. 血液指标对早产儿视网膜病变影响的研究进展[J]. 国际眼科杂志, 2024, 24(3): 392-396.
[11]	Glaser K, Härtel C, Dammann O, et al. Erythrocyte transfusions are associated with retinopathy of prematurity in extremely low gestational age newborns[J]. Acta Paediatr, 2023, 112(12): 2507-2515.
[12]	祁馨仪, 李博巍, 李贝, 等. 妊娠期上呼吸道病毒感染对妊娠结局的影响及不同时期上呼吸道病毒感染对孕产妇及胎儿的影响[J]. 宁夏医学杂志, 2024, 46(2): 104-107.
[13]	Hwang JH, Lee EH, Kim EA. Retinopathy of prematurity among very⁃low⁃birth⁃weight infants in Korea: incidence, treatment, and risk factors[J]. J Korean Med Sci, 2015, 30(): S88-94.
[14]	Fu M, Song W, Yu G, et al. Risk factors for length of NICU stay of newborns: a systematic review[J]. Front Pediatr, 2023, 11: 1121406.
[15]	McPherson C. Eyesight to the blind⁃pharmacotherapy for retino⁃pathy of prematurity[J]. Neonatal Netw, 2023, 42(2): 88-95.
[16]	Boskabadi H, Abrishami M, Shoeibi N, et al. Incidence of retinopathy of prematurity in neonates with neonatal sepsis[J]. Arch Iran Med, 2023, 26(5): 248-251.

因素	非ROP组（n=171）	ROP组（n=71）	χ²/t值	P值
母亲围产期情况
阴道分娩	65（38.0）	13（18.3）	8.915	0.003
多胎妊娠	106（62.0）	22（31.0）	19.353	<0.001
试管妊娠	83（48.5）	22（31.0）	6.292	0.012
妊娠期糖尿病	40（23.4）	45（63.4）	35.206	<0.001
妊娠期高血压	48（28.1）	38（53.5）	14.186	<0.001
极低出生体重儿情况
男性	81（47.4）	33（46.5）	0.016	0.900
胎龄（x±s，周）	30.6±9.2	30.4±8.5	0.157	0.875
出生体质量（x±s，g） 1 289.4±203.4		1 103.3±201.6	6.497	<0.001
宫内感染	43（25.1）	56（78.9）	59.908	<0.001
住院期间治疗措施
气管插管	45（26.3）	22（31.0）	0.547	0.460
机械通气	8（4.7）	9（12.7）	4.913	0.027
输血治疗	15（8.8）	28（39.4）	32.287	<0.001
吸氧时间>5 d	45（26.3）	66（93.0）	89.737	<0.001

变量	赋值
妊娠期高血压	是=1，否=0
阴道分娩	是=1，否=0
多胎妊娠	是=1，否=0
试管妊娠	是=1，否=0
机械通气	是=1，否=0
妊娠期糖尿病	是=1，否=0
出生体质量	原值代入
宫内感染	是=1，否=0
吸氧时间>5 d	是=1，否=0
输血治疗	是=1，否=0

影响因素	β值	SE值	Wald值	OR	P值	95%CI
常数项	1.612	1.838	0.770	5.015	0.380
阴道分娩	-0.847	0.646	1.721	0.429	0.190	0.121~1.520
多胎妊娠	-0.953	0.582	2.688	0.385	0.101	0.123~1.205
试管妊娠	-0.703	0.598	1.385	0.495	0.239	0.153~1.597
妊娠期糖尿病	1.692	0.589	8.243	5.430	0.004	1.711~17.236
妊娠期高血压	1.042	0.578	3.245	2.835	0.072	0.912~8.810
出生体质量	-0.574	0.012	3.940	0.563	0.176	0.245~1.293
宫内感染	2.156	0.595	13.146	8.638	<0.001	2.693~27.709
机械通气	1.186	1.234	0.925	3.275	0.336	0.292~36.756
输血治疗	2.098	0.776	7.318	8.151	0.007	1.783~37.273
吸氧时间>5 d	4.005	0.722	30.739	54.867	<0.001	13.318~226.036

Analysis of risk factors for retinopathy in very low birth weight infants

RichHTML

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

Figures/Tables 3

References 16

Related Articles 15

Recommended Articles

Metrics

Comments

[1]	. Clinical practice guidelines for integrative Chinese and western medicine in children with enuresis (2025) [J]. Chinese Pediatrics of Integrated Traditional and Western Medicine, 2025, 17(3): 185-198.
[2]	Yuanjun LU, Na CHEN, Yang YANG, Man CHENG, Duojian LI, Qiuyue LI, Zhu CHEN. Differentiated treatment for central precocious puberty based on the five viscera and the theory of "Tiangui" [J]. Chinese Pediatrics of Integrated Traditional and Western Medicine, 2025, 17(3): 203-207.
[3]	Junchao LIU, Jiaojiao LIU, Hong XU. Retrospective analysis of liver⁃softening and spleen⁃strengthening therapy for children with precocious puberty of spleen⁃deficiency and liver⁃hyperactivity type [J]. Chinese Pediatrics of Integrated Traditional and Western Medicine, 2025, 17(3): 208-212.
[4]	Hongyan SHEN, Xuefeng WANG, Xinmin HAN, Bin YUAN, Siyuan HU, Xinmin LI, Lei XIONG, Ping HE, Ying ZHOU, Xuerong ZHANG, Jingwen MU. Clinical study on the treatment for children with acute tonsillitis (external wind⁃heat syndrome) with Bangbo Ruexiao granule [J]. Chinese Pediatrics of Integrated Traditional and Western Medicine, 2025, 17(3): 213-220.
[5]	Yihan XIE, Siying MEI, Xilian ZHANG. Research progress on evaluation indexes for clinical trials of infantile epileptic spasms syndrome [J]. Chinese Pediatrics of Integrated Traditional and Western Medicine, 2025, 17(3): 221-225.
[6]	Lingyan XUE, Jianying LI, Chunlan HE, Lingli ZHAO. Impact of short chain fatty acids and microbial community structure in feces on infants and young children [J]. Chinese Pediatrics of Integrated Traditional and Western Medicine, 2025, 17(3): 226-230.
[7]	Lijuan ZHENG, Fumin XUE, Jing YU. Diagnostic value of GGT combined with DBIL for biliary atresia in different age groups of children [J]. Chinese Pediatrics of Integrated Traditional and Western Medicine, 2025, 17(3): 231-236.
[8]	Haifei XIAO, Na WANG. Clinical observation of Xiaoer Dingchuan oral solution combined with western medicine treatment in the treatment of children with asthmatic bronchitis [J]. Chinese Pediatrics of Integrated Traditional and Western Medicine, 2025, 17(3): 242-245.
[9]	Shengze ZHENG, Yanhong QIN, Feng ZHANG. Professor Qin Yanhong's clinical experience in differentiated treatment of functional constipation in children with the "multi⁃organ coordination" concept [J]. Chinese Pediatrics of Integrated Traditional and Western Medicine, 2025, 17(3): 251-255.
[10]	Zicheng ZHAO, Siyu WU, Pengfei YAN. Acupuncture combined with drug therapy in the treatment of childhood tic disorder based on the theory of Midnight⁃noon Ebb⁃flow [J]. Chinese Pediatrics of Integrated Traditional and Western Medicine, 2025, 17(3): 256-259.
[11]	Shiqing XU, Bin XIE, Xuefeng WANG. Professor Wang Xuefeng's experience in treating functional abdominal pain in children based on the theory of "treating middle Jiao through balancing" [J]. Chinese Pediatrics of Integrated Traditional and Western Medicine, 2025, 17(3): 260-263.
[12]	Yali CUI, Ke CHANG. Data mining of medication rules of Professor Chang Ke in the treatment of cough in children [J]. Chinese Pediatrics of Integrated Traditional and Western Medicine, 2025, 17(3): 264-269.
[13]	Bo QI, Yuyan CHEN, Xiaoming WANG, Shen CHENG. Exploration of molecular mechanism of Tiaohe Zhidong prescription in the treatment of childhood tic disorders based on network pharmacology and molecular docking technology [J]. Chinese Pediatrics of Integrated Traditional and Western Medicine, 2025, 17(3): 270-276.
[14]	SHEN Hongyan, ZHANG Xiuying, TAN Chunying, SHANG Tao, MENG Bin, MU Jingwen, TIAN Zhifan, E Mingxin, WANG Xuefeng. A multi center clinical study on the adjuvant treatment with Fuxiong powder for children with Mycoplasma pneumoniae pneumonia [J]. Chinese Pediatrics of Integrated Traditional and Western Medicine, 2025, 17(2): 93-98.
[15]	WU Pan, HUANG Tingyue, ZHANG Zhanling, WANG Xuefeng. Meta analysis and GRADE evaluation of Xiaoer Feire Kechuan oral liquid in the treatment of Mycoplasma pneumoniae pneumonia [J]. Chinese Pediatrics of Integrated Traditional and Western Medicine, 2025, 17(2): 98-108.