Objective ：To investigate the effect of point injection of mouse nerve growth factor(mNGF) combined with head acupuncture in treatment of children with autism.

 Methods： A total of 59 cases of children with autism aged 24～60 months,were divided into 3 groups according to the time of hospital visit and under the permission of parents:conventional rehabilitation training group(group A,15 cases)，conventional rehabilitation training+head acupuncture group(group B,22 cases);conventional rehabilitation+head acupuncture+point injection group(group C,22 cases).The children were evaluated by ABC and CARS and PPVT scales before and after treatment.

Results： ABC score and CARS score were significantly decreased while PPVT score was increased in group B and C,the difference being statistically significant(P<0.05).The treatment effect was better in group C than in group B,the difference being statistically significant(P<0.05).

Conclusion： Point injection of mNGF combined with head acupuncture and simple head acupuncture are both effective for 2～5-year old children with autism,but the effect of the former is better than the latter.