ISSN 1674-3865  CN 21-1569/R
主管：国家卫生和计划生育委员会
主办：中国医师协会
　　　辽宁省基础医学研究所
　　　辽宁中医药大学附属医院
Chinese Pediatrics of Integrated Traditional and Western Medicine

Chinese Pediatrics of Integrated Traditional and Western Medicine ›› 2010, Vol. 2 ›› Issue (1): 12-14.doi: 10.3969/j.issn.1674-3865.2010.01.005

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Preliminary investigation of relationship between oxytocin receptor gene and childhood autism

JIANG Zhimei,ZHANG Lihua,LV Zhihai,et al   

  1. Department of Development and Behavior Pediatrics,The 3rd Affiliated Hospital of Jiamusi University，The Laboratory of Child Neurological Rehabilitation of Jiamusi University,Jiamusi 154003,China
  • Online:2010-02-25 Published:2019-06-03

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Abstract: ObjectiveTo investigate the relationship between oxytocin receptor（OXTR）gene polymorphism and childhood autism in Han population in Jiamusi.
MethodsPolymerase chain reactionrestricted fragment length polymorphism(PCRRFLP) was used to determine allele and genotype of SNP(rs2254298) of OXTR in 30 Chinese Han autism children staying in the 3rd Affiliated Hospital of Jiamusi University and 30 normal children in a kindergarten and an elementary school in Jiamusi from May to December,2007.
ResultsThe genotype distribution of the SNP(rs2254298) in patient group and control group was consistent with the HardyWeinberg equilibrium(P>0.05).There was significant difference in the distribution of the allelic frequencie and genotype in rs2254298 between the two groups(P＜0.05).
ConclusionsThere is an association between the SNP(rs2254298) of OXTR and childhood autism.

Key words: Autism;Developmental disorders;Receptor, oxytocin;Child