哮喘儿童呼出气一氧化氮与肺功能、激发试验、哮喘控制测试评分相关性研究

doi:10.3969/j.issn.1674-3865.2014.02.009

Abstract

Abstract:
Objective:To investigate the levels of fractional exhaled nitric oxide(FeNO) and their relationship with lung function（FEV1）,CACT score of the children with asthma in acute onset and paracmasis periods and the relationship between FeNO level and exercise challenge test in the children with asthma in paracmasis period.
Methods:A total of 135 cases of asthma in acute onset, 115 cases in paracmasis and 140 cases of healthy children were selected from Department of Allergy in our hospital. All subjects were determined for FeNO, lung function（FEV1） and CACT score, and the FeNO level correlation with lung function (FEV1) and CACT score in the various period of asthma were analyzed. At the same time, clinical paracmasis in asthma children had exercise challenge test, and the relationship of FeNO level in paracmasis with exercise challenge test was analyzed.
Results:(1) There were significant differences between the asthma acute onset group and the control group in the levels of FeNO and FEV1（P＜0.000 1）.There were significant differences between the asthma acute onset group and the paracmasis group in the levels of FeNO and FEV1（P＜0.000 1）.There were significant differences between the paracmasis group and the control group in the levels of FeNO（P＜0.0001）.There were no significant differences between the paracmasis group and the control group in the levels of FEV1（P>0.05）.(2) The negative correlation between FeNO and FEV1 was found in the asthma acute onset group（r=-0.181，P=0.035）, but not in the paracmasis group and the control group.(3) The positive correlation between FeNO and exercise challenge test was found in the paracmasis group（r=0.230，P=0.013）.(4) The negative correlation between FeNO and CACT score was found in the asthma acute onset group and the paracmasis group（r=-0.213，P=0.013，r=-0.209，P=0.025）.
Conclusion:The levels of FeNO may be useful to evaluate and control degree in patients with asthma. Exercise challenge test is a simple method of assessing asthma airway hyperresponsiveness.

Key words: asthma, nitric oxide, lung function, exercise challenge test, children

GAO Hong，LIU YanLin, CHEN Shen, et al. . The study of fractional exhaled nitric oxide(FeNO) and its relationship with lung function, exercise challenge test, CACT score in the children with asthma[J]. Chinese Pediatrics of Integrated Traditional and Western Medicine, 2014, 6(2): 119-122.

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The study of fractional exhaled nitric oxide(FeNO) and its relationship with lung function, exercise challenge test, CACT score in the children with asthma

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