肌肽预处理对缺氧缺血后大鼠认知功能的影响

doi:10.3969/j.issn.1674-3865.2014.02.010

Abstract

Abstract:
Objective:To explore the effects of carnosine pretreatment on cognitive function in hypoxic ischemia (HI) rats.
Methods:A total of 36 SD rats，7 days after birth,were ligated and cut off the left common carotid artery;they inhaled 8% oxygen and nitrogen mixture for 2 h to induce HI，and then these SD rats were randomly divided into 3 groups (n=12)：(1) carnosine pretreatment group：given intraperitoneal injection of carnosine 250 mg/kg at a time 30 min before the HI induction；(2) the HI groups：under the same condition , the same volume of physiological saline was used instead；(3) control group：no treatment or management was given.Some 21~26 days after HI, by Morris water maze experiment——navigation trial and space probe trial，the effect of carnosine on swimming time，distance，and percentage of time spent in the target quadrant was evaluated.
Results:Carnosine pretreatment reduced swimming time，shortened swimming distance，and increased percentage of time spent in the target quadrant of HI rats.
Conclusion:Carnosine pretreatment improves the cognitive function of the HI rats，hence effectively plays its role in the nerve protection.

Key words: hypoxicischaemic cerebropathy, asphyxia, carnosine, diagnosis application, cognitive function, rat, animal, test

ZHANG Xiangmin，ZHANG Zhan，CHENG Xiuyong，et al.. The effect of carnosine pretreatment on cognition function of HI rat[J]. Chinese Pediatrics of Integrated Traditional and Western Medicine, 2014, 6(2): 122-125.

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The effect of carnosine pretreatment on cognition function of HI rat

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