Objective：To observe the levels of CXCL16,a disintegrin and metalloprotease 10(ADAM10) in children with primary nephrotic syndrome(PNS) before and after intervention of traditional Chinese medicine Shenkangling,and to clarify the mechanism of PNS and the action of Shenkangling by molecular biology.

Methods：PNS children were randomly divided into the Shenkangling + western medicine group(n=30) and the western medicine group(n=30),and healthy children as normal control group were selected in the examination center(n=30).Serum CXCL16,ADAM10 were detected by ELISA in children with PNS before and after treatment, and at the same time, serum albumin(ALB), cholesterol(CH) and 24hour urinary protein excretion efficacy evaluation were detected.
Results：In PNS children urinary protein excretion was elevated, serum ALB reduced,CH increased,CXCL16 and ADAM10 content increased(P<0.01).Compared to western medicine group, in Shenkangling + western medicine group CH and serum CXCL16 and ADAM10 content was reduced, serum ALB increased more significantly(P<0.01 or P<0.05).Both in Shenkangling + western medicine group and in western medicine group urine protein was decreased, but there was no difference between them.

Conclusion：CXCL16 and ADAM10 are involved in the pathogenesis of PNS,and traditional Chinese medicine Shenkangling can significantly reduce the levels of serum CXCL16 and ADAM10,reduce the urine protein and CH and elevate ALB, thus improving symptoms in children, which may be related to removal of serum CXCL16 by clearing up oxLDL.