Abstract: Objective：To observe the effects of Huaiqihuang granule plus glucocorticoid on the immune function of children with primary nephrotic syndrome(PNS).
Methods：A total of 52 children with primary nephrotic syndrome were divided into two groups randomly.The treatment group(n=26) was treated with Huaiqihuang grannule plus prednisone；the control group(n=26) was treated with prednisone only. Observe the time of proteinuria turning negative and the change of IgG，IgA，IgM and CD3，CD4，CD8 and CD4/CD8 after eight weeks of treatment.
Results：The time of proteinuria turning negative in the treatment group was significantly shorter than that in the control group(P＜0.05)；IgG，CD3，CD4 and CD4/CD8 of the treatment group were significantly improved(P＜0.01)；both differences were of statistical significance(P<0.05 and P<0.01)；CD8 was lower than the control group, but there was no statistically significant difference(P＞0.01)；IgA and IgM in the treatment group were slightly increased, but there was no statistically significant difference between the two groups(P＞0.01).
Conclusion：Huaiqihuang granule plus prednisone in the treatment of primary nephrotic syndrome can shorten the time of proteinuria turning negative, and has a good effect in the regulation of humoral and cellular immunity.

Key words: primary nephrotic syndrome, Huaiqihuang granules, T lymphocyte subsets, immunoglobulin, children