Abstract:
Objective：To observe the clinical effect of ambroxol hydrochloride in the treatment of acute respiratory distress syndrome(ARDS) in term neonates with several asphyxia.Methods：A total of 60 severe asphyxia neonates with ARDS admitted to Jingchuan People's Hospital of Gansu Province from October 2012 to October 2014 were randomly divided into two groups:28 cases in control group and 32 cases in observation group. The control group was given basic treatment, and the observation group was treated with ambroxol hydrochloride in addition to the basic treatment. Observe the time for respiratory distress to get relieved and the NBNA at the end of two weeks of treatment in the two groups. The clinical mortality, complications due to hypoxia, mechanical ventilation and improvement on chest Xray at two days were also observed.
Results：The relief time in the observation group was (4.0±1.1)d，which was shorter than that of the control group［（7.0±1.5）d］. The NBNA score at two weeks was 38.15±3.50，which was higher than the control group（35.49±2.19），the difference being of statistical significance（P＜0.05）.The occurrence rate of complications，clinical mortality and rate of mechanical ventilation in the observation group were all lower than those of the control group，and the rate of improvement on chest Xray at two days was higher than the control group，all the differences being of statistically significance(P＜0.05).
Conclusion：In the treatment of ARDS children with severe asphyxia，ambroxol hydrochloride can significantly shorten the time for distress symptoms to get relieved，reduce the complication rate and mortality，resulting in the improvement of the child patients.

Key words: Respiratory distress syndrome;Asphyxia, Ambroxol hydrochloride, therapeutic application, Infant, Newborns