Abstract:
Objective：To study the clinical features of atypical hand, foot and mouth disease.
Methods：The clinical data of 122 patients with atypical hand, foot and mouth disease in N0.6 Internal Ward in Dalian Woman and Children's Hospital between Jun. 2013 to Sep. 2013 were collected and analyzed.
Results：Peak incidence of atypical hand, foot and mouth disease occurred in Aug. 2013.Frequency of vesicles and papules over ears, faces, trunks and limbs were 62%（76/122）,69%(84/122),66%（81/122）and 100%（122/122）respectively. About 21%（26/122）patients had mucous involved besides oral mucous, and 19%(23/122) patients had severe hand, foot and mouth disease. All patients fully recovered. Positive detection rate on EV71 was 1%(1/91),CA16 1%(1/91),CA10 0(0/93) and CA6 84%(78/93). About 45%(44/97) patients developed onychomadesis 1 week to 2 months after onset of atypical hand, foot and mouth disease.ConclusionCA6 is the main pathogen of 122 patients with atypical hand, foot and mouth disease in Dalian in 2013，and the peak incidence occurs in August. Atypical hand, foot and mouth disease involves skin and mucous extensively. Some patients progress to severe cases and develop onychomadesis during the recovery period, but prognosis is good.

Key words: Atypical hand, foot and mouth disease, diagnosis, CA6, Children