Abstract:
Objective：To observe the prevention effect of montelukast sodium on wheezing in children with acute upper respiratory tract infection.
Methods：Totally 126 cases of children of 1-to 3-year-old with previously wheezing attack for more than two times after acute upper respiratory tract infection were divided into two groups: 66 cases for A group, 60 cases for B group. After basic symptomatic treatment, children in A group were treated with oral montelukast sodium at 4 mg once daily within 24 hours after the disease attack, and the treatment lasted for 10 days. Children in B group were treated with oral montelukast sodium at 4 mg once daily after the appearance of wheezing symptom, and the treatment also lasted for 10 days. According to crossover principle, we performed cross comparison of the two groups if children were diagnosed with acute upper respiratory tract infection again 3 months after stopping taking montelukast sodium. The cases of wheezing were observed and recorded.
Results：The number of children in A group with wheezing and serious wheezing was lower than that in B group before cross comparison. However, after cross comparison, the number of children with wheezing and serious wheezing in A group was higher than that in B group.
Conclusion：Montelukast sodium has preventive effect on wheezing in children between 1- to 3-year-old with acute upper respiratory tract infection. Early application can reduce the rate of wheezing attack and alleviate the severity.

Key words: Acute upper respiratory tract infection, Wheezing, Montelukast sodium, treatment application, Children