ISSN 1674-3865  CN 21-1569/R
主管:国家卫生和计划生育委员会
主办:中国医师协会
   辽宁省基础医学研究所
   辽宁中医药大学附属医院

Chinese Pediatrics of Integrated Traditional and Western Medicine ›› 2016, Vol. 8 ›› Issue (1): 64-66.doi: 10.3969/j.issn.1674-3865.2016.01.024

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Observation on the clinical effects of minocycline combined with methylprednisolone in the treatment of children with refractory mycoplasma pneumoniae pneumonia

RAO Fuguang,XIONG Biao,WANG Peiqin   

  1. Department of Pediatrics,Maternity and Child Health Care Hospital of Longgang District,Shenzhen 518172,China
  • Published:2016-02-25 Online:2018-11-19

Abstract:
Objective:To observe the clinical effects of minocycline combined with methylprednisolone in the treatment of children with refractory mycoplasma pneumoniae pneumonia(RMPP).
Methods:Totally 88 children with RMPP who accepted treatments in Department of Pediatrics,Maternity and Child Health Care Hospital of Longgang District,from March 2014 to March 2015,were taken as the research subjects,and these patients were randomly divided into the control group and the observation group,with 44 patients in each group.In the control group,they were treated with azithromycin for routine treatment,while in the observation group,they were treated with azithromycin for 1 week and then oral minocycline was taken,medication continuing for 5 d;at the same time they were treated with the intravenous infusion of methylprednisolone for 5 d,then it was changed to oral prednisone,the dosage being reduced gradually according to patients' condition for 7 days.Then,the symptom relief time,hospitalization time,inflammation index and adverse reaction of the two groups were observed.
Results:The cough relief time,cooling time and hospitalization time of children in the observation group were significantly shorter than those in the control group,and the difference was statistically significant(P<0.05).After treatment,the levels of inflammatory markers of the two groups were significantly lower than before treatment,and the difference was statistically significant(P<0.05).After treatment,the C reaction protein,ESR and WBC count in the observation group were significantly lower than those in the control group,and the difference was statistically significant(P<0.05).After two weeks of treatment,the lung shadow absorption rate in the observation group was 81.82%(36/44),which was significantly higher than that in the control group[43.18%(19/44)] and the difference was statistically significant(P<0.05).
Conclusion:In the clinical treatment for RMPP,combination with methylprednisolone and minocycline can rapidly improve the clinical symptoms and thus improve the treatment effect.

Key words: Refractory mycoplasma pneumoniae pneumonia, Methylprednisolone, Minocycline, Children