Abstract:
Objective:To understand epidemiological characteristics and pathogenic features of hand-foot-and-mouth disease in Dalian from year of 2010 to 2013.
Methods:Analyze clinical data of 28 479 hand-foot-and-mouth disease cases treated in Dalian Children′s Hospital from January 2010 to December 2013.Clinical severe children′s feces or throat formula was sent for detection,and the two pathogens of EV71 and CA16 were detected.Observe the status in each month of hand-foot-and-mouth disease,time distribution of in-patient cases and severe hand-foot-and-mouth disease cases，and result of severe children′s enterovirus.
Results:The largest quantity of cases was 7 587 in year of 2012,and this number increased each year in May,and the infection number occupied 7397%～8373% of the whole year， especially from June to August every year.The infection peak month was in July from 2010 to 2012 and August in 2013,and it declined obviously in September.
Conclusion:Most cases of hand-foot-and-mouth disease in 2010 are associated with EV71 infection and the largest quantity of hand-foot-and-mouth disease case is in year of 2012 which is probably associated with CA16 infection.Most atypical hand-foot-and-mouth disease cases are in 2013 and disease peak moves from July of 2010～2012 to August of 2013,which is probably associated with CA6 infection.

Key words: Hand-foot-and-mouth disease, Epidemiological characteristics, Pathogenic features, Children