Abstract:
Objective：To observe the effect of Fuling nutrient mixture on the body weight, blood fat and histopathology of the immature rats with simple obesity, and explore the new way of healing the simple obesity.
Methods：Divide the 40 one-month rats into four groups, including Fuling group(Fuling+normal diet), Fuling nutrient mixture group(Fuling+vitamin B1, vitamin B2+normal diet)， model control group(normal diet) and blank control group(normal diet), each group with 10 rats. Feed the first three groups with high fat diet for 6 weeks, and make the models. Observe the following indicators of the rats：body weight, body fat, blood fat and histopathology.
Results：(1)For the two groups of young rats, Fuling(Fuling+normal diet) and Fuling nutrient mixture group(Fuling+vitamin B1，B2+normal diet), compared with the model control group， body fat content was of no statistically significant difference(P>0.05)， but there was a statistically significant difference(P<0.05) in body quality growth. Between these two groups body quality growth and body fat content were of no significant difference in statistics.(2)Triglyceride(TG) levels of those two groups and the blank control group were lower than those of model control group, the difference being significant in statistics（P＜0.01）.High density lipoprotein(HDL-C) level of the two groups was higher than that of the model group, the difference being statistically significant(P<0.05). There were no differences(P>0.05) in either triglyceride(TG) levels or high density lipoprotein(HDL-C) levels between those two groups. Compared with the model group，total cholesterol(TC) levels and low-density lipoprotein(LDL-C) levels of those two groups remained no significant difference(P>0.05) in statistics.(3)Histopathologic morphology of the liver tissues of the two groups after treatment was close to normal.
Conclusion：Fuling can decrease the weight and the triglyceride of the rats with simple obesity, increase the high-density lipoprotein, and recover the physiomorphology of the liver.

Key words: Simple obesity, Fuling, Blood fat, Histopathology, Rat