Abstract: Objective:To study the clinical significance of early intervention and follow-up in the development of high risk infants.
Methods:Totally 106 cases of high risk infants who accepted the intervention and follow-up immediately after birth were included as neonatal intervention group, 58 cases of high risk infants who accepted intervention one month after birth were included as infant intervention group, and 120 cases of healthy neonates were included as the control group; regular follow-up and evaluation were performed. Observe the physical development at six months and 12 months after birth in the three groups. In the neonatal intervention group and control group, neurological behavior was determined at 1 week and 4 weeks after birth. Observe the gross motor development, primitive reflex disappearance and establishment time of posture reflex.
Results：At 6 months after the birth the body length, weight and head circumference of neonatal and infant intervention group were lower than the control group with statistical difference(P<0.05); at 12 months after birth the height, weight and head circumference of three groups showed no statistical difference(P>0.05); 1 week after birth the NBNA score of neonatal intervention group was lower than the control group(P<0.05); 4 weeks after birth the NBNA scores of the two groups had no statistical difference(P>0.05); the establishment time of gross motor development in sitting, crawling and postural reflex of the neonatal intervention group and the control group had no statistical difference(P>0.05),which were better than those of infant intervention group, and the difference was statistically significant(P<0.05); gross motor development in rising, turning over and the disappearance time of primitive reflex in all these groups had statistical difference(P<0.05).
Conclusion：Early intervention and regular follow-up have important clinical significance in the recovery and development of high risk infants.

Key words: High risk infants, Intervention and follow-up, Neurological behavior score