Abstract: Objective:To investigate the therapeutic effect of triple drug therapy combined with L-GMI collutory in the eradication of Helicobacter pylori(H. pylori) infection in children.
Methods:From January 2010 to December 2014, in Affiliated Hospital of Jiangsu University, 120 H. pylori positive cases confirmed by 13C- breath test in the outpatient department of pediatrics were randomly divided into observation group and control group, each with 60 cases. Control group was treated with omeprazole+clarithromycin+amoxicillint, while the observation group was treated with L-GML collutory in addition to the treatment for control group for 2 weeks. Observe the curative effect in 7 d and 14 d after the treatment, the eradication rate of H. pylori after drug withdrawal for 4 weeks and the recurrence rate after 1 year.
Results：The total effective rate of the observation group was 90%(54/60) and 96.7%(58/60) after 7 and 14 days, which was higher than that in the control group(73.3%,44/60) and （83.3%,50/60), and the difference was statistically significant(P<0.05). The eradication rate of H. pylori in the observation group was 80%(48/60), higher than that in the control group(53.3%,32/60), the difference being statistically significant(P<0.01). The recurrence rate of H. pylori in the observation group was 14.6%(7/48), lower than that in the control group(37.5%,12/32), and the difference was statistically significant(P<0.05).
Conclusion：Conventional drug therapy combined with L-GMI collutory can significantly improve the cure rate and decrease the recurrence rate of H. pylori in children.

Key words: Helicobacter pylori infection, Drug therapy, L-GMI, Children