Abstract: Objective:To analyze the changes of plasma pre albumin(prealbumin, PA) and white blood cell count(total leukocyte count, TLC) in patients with Kawasaki's disease in order to investigate the significance of combined analysis of PA and TLC changes in predicting coronary artery disease.
Methods:A retrospective analysis of 83 cases of children with Kawasaki's disease in our hospital from January 2013 to January 2016 were carried out. Analyze the case data，which included the plasma level of TLC, PA and the Results: of ultrasound examination of the coronary artery, etc. Use t test, Chi-square test and area under the ROC curve and the calculation of the cut-off value of statistical Methods to analyze the correlation between PA, TLC and the coronary artery disease.
Results:In the acute phase of patients with Kawasaki, the plasma Mg level was (72.39±46.81)×109/L PA, which was significantly decreased compared with the normal reference value, and the TLC count was (16.47±6.49)×109/L, which was significantly higher than the normal reference value, and the difference was statistically significant(P＜0.05). The ROC curve was used to calculate the area of PA, and the AUC was 0.699, which was of diagnostic value. When the threshold value of PA level was 48.5 mg/L, the sensitivity and specificity of predicting coronary artery dilatation were 73.3% and 64.5%, respectively.
Conclusion：PA and TLC have significant changes in the acute stage of Kawasaki's disease. Combined analysis of changes in PA and TLC may have important implications for the prediction of coronary artery disease, but can not be used to judge the type and extent of coronary artery disease.

Key words: Kawasaki disease, Coronary artery disease, Pre albumin, ROC curve, Child