Abstract: Objective:To observe the clinical effect of fluticasone propionate aerosol combined with montelukast sodium chewable tablet in treating cough variant asthma in children with mite allergies.
Methods:From March 2014 to March 2016, 90 children with cough variant asthma who were allergic to mites were enrolled in Department of Pediatrics, Chang'an Hospital of Dongguan City, and were divided into control group and observation group by digital random method. The control group was treated with fluticasone propionate aerosol, and the observation group was given montelukast sodium chewable tablets in addition to the treatment for control group, 3 months as a course of treatment; the two groups were treated for 2 courses. Observe the clinical effect, day cough score, night cough score, and the pulmonary function indexes, such as FEV1, peak expiratory flow rate(PEF) and FEV1% of the two groups. The recurrence of the two groups and the incidence of adverse reactions were also observed.
Results:The total effective rate in the observation group was 91.1%(41/45), which was significantly higher than that in the control group(75.6%, 34/45); the difference was significant(P<0.05). The cough score, cough remission and disappearance time were significantly better in the observation group than those in the control group(P<0.05). The FEV1, PEF and FEV% of the two groups after treatment were significantly higher than those before treatment(P<0.05). The FEV1, PEF and FEV% of the observation group were significantly better than those of the control group(P<0.05). There was no significant difference in the recurrence rate and adverse reaction rate between the two groups(P>0.05).
Conclusion：Clinical application of fluticasone propionate nasal spray combined with montelukast sodium chewable tablets in the treatment of mite-allergic children with cough variant asthma has a significant clinical effect, which can effectively improve the clinical symptoms of children, and is safe and reliable, so it should be clinically promoted and used.

Key words: Cough variant asthma, Fluticasone propionate aerosol, Montelukast sodium chewable tablets, Mite allergy, Children