Abstract: Objective:To investigate the relationship between the levels of blood lactate and procalcitonin and the prognosis of sepsis in children in order to reduce the mortality of sepsis.
Methods:From March 2013 to February 2016, 53 patients with sepsis were admitted to Pediatric Department of Laibin People 's Hospital. According to the prognosis, the patients were divided into survival group(38 cases) and death group(15 cases). The levels of blood lactate and procalcitonin were compared between the two groups. According to the blood lactate level, the 53 cases of sepsis were divided into 3 groups, 27 cases(<2.0 mmol/L) in low lactic acid group(A), 17 cases in the medium lactic acid group(2.0~3.9 mmol/L)(B) and 9 cases in the high lactic acid group(≥4.0 mmol/L)(C). The survival and death rate of the three groups(0.05~2.0 μg/L) were compared. According to the level of procalcitonin, these patients were divided into 4 groups:5 cases(<0.05 μg/L) in normal group(D),15 cases(0.05~2.0 μg/L) in slight increase group(E),8 cases(2.1~10 μg/L) in moderate increase group(F) and 15 cases(>10 μg/L) in significant increase group(G).The survival rate and mortality of the four groups were compared. The ROC curves in predicting death were compared(P<0.01).
Results:The levels of blood lactate and procalcitonin in the survival group were significantly lower than those in the death group(P<0.05). When the lactate level was moderately increased,the mortality increased significantly, similar to the survival rate, and there was no statistal difference(P>0.05).When the level of procalcitonin increased to a moderate or significant level, the mortality increased significantly, and the survival rate was significantly higher than that of the survival rate(P<0.05), the difference being statistically significant(P<0.05). The prediction of sepsis mortality was more accurate when blood lactate levels were ≥2.0 mmol/L(especially≥4.0 mmol/L) and procalcitonin>2.0 μg/L(especially>10 μg/L).
Conclusion：The levels of blood lactate and procalcitonin are closely related to the prognosis of sepsis, and the combined detection of serum lactic acid and procalcitonin may be more helpful to evaluate the situation and prognosis of sepsis.

Key words: Sepsis, Blood lactate, Procalcitonin, Prognosis, Children