Abstract:
Objective: To observe the clinical characteristics,diagnosis and treatment of infantile cytomegalovirus(CMV)infection.
Methods: From Oct.2014 to Oct.2016,72 children with CMV infection were admitted to the Infant Department of Zhengzhou Children′s Hospital.Serum CMV-IgM was detected by enzyme-linked immunosorbent assay(ELISA),and the children whose level of CMV-DNA-PCR was higher than that of normal group by PCR fluorescent probe were found. The 72 cases of children were given ganciclovir treatment, and the treatment was divided into induction therapy and maintenance therapy. The following examinations were performed: routine blood test, liver and kidney function, chest X-ray, cerebral CT, brainstem auditory evoked potential and ultrasonography. Meanwhile, the CMV-DNA-PCR of mothers were detected, and its clinical manifestations and diagnosis and treatment were analyzed.
Results: The clinical manifestations included infantile hepatitis in 45 cases, hyperbilirubinemia in 35 cases, pneumonia in 31 cases, brain injury in 18 cases, brainstem auditory evoked potential abnormality in 9 cases, malnutrition in 6 cases, congenital heart disease in 5 cases and hereditary metabolic diseases in 3 cases. The milk CMV-DNA-PCR of 45 mothers was higher in the 60 mothers of breast feeding. Totally 65 cases were improved or cured after treatment, and 7 cases gave up treatment.
Conclusion: Small infants are prone to CMV infection, and the clinical manifestations are various, with hepatobiliary system abnormalities most common. For children diagnosed with CMV infection, CMV-DNA-PCR of mother's milk should be detected simultaneously and early intervention should be performed. Ganciclovir antiviral treatment produces good prognosis in most cases, and early diagnosis and treatment is helpful to improve the prognosis.

Key words: Cytomegalovirus infection, Clinical features, Diagnosis and treatment, Baby