Abstract: Objective:To explore the clinical effect of soybean granule combined with ribavirin aerosol for children with hand-foot-mouth disease(HFMD).
Methods:A total of 78 children with HFMD, who were treated in our hospital from February 2015 to February 2016, were randomly divided into observation group and control group(39 cases in each group). The patients in the control group were treated with aerosolized ribavirin. The patients in the observation group were treated with the combination of children's soybean granules and ribavirin aerosol. Seven days after treatment, the effect in the two groups of pediatric patients, the corresponding clinical signs and symptoms and the adverse reactions were compared.
Results:The total effective rate was 97.44% in the observation group and 82.05% in the control group. The total effective rate in the observation group was significantly higher than that in the control group(P<0.05). The time of fever subsidence, the time of rash disappearance and the recovery time were shorter in the observation group than in the control group. There was significant difference between the two groups (P<0.05). The adverse reaction rate was 2.56% in the observation group and 23.08% in the control group. There was a significant difference between the two groups(P<0.05).
Conclusion:The treatment for pediatric hand-foot-mouth disease with the combination of pediatric soybean granules and ribavirin aerosol have a high efficacy and a low incidence of clinical adverse reactions, with high safety and convenient and simple administration. It should be promoted in clinical treatment.

Key words: Hand-foot-mouth disease, Pediatric soybeans granule, Ribavirin aerosol, Curative effect analysis, Children