Abstract:
Objective：To investigate the value of plasma N terminal brain natriuretic peptide(NT-proBNP) in the diagnosis of heart failure after neonatal asphyxia.
Methods：A total of 120 neonates with asphyxia treated in our hospital from Jan. 2014 to Mar. 2015 were divided into two groups according to whether they had heart failure: group A(55 cases of neonates with heart failure) and group B(65 cases without heart failure).NT-proBNP, cardiac troponin(cTnI),lactate dehydrogenase(LDH1) and creatine kinase isoenzyme(CK-MB) were detected in the two groups.
Results：NT-proBNP,LDH1,CK-MB and cTnI were significantly higher in group A than in group B, the difference being of statistical significance(P<0.05).Unconditioned Logistic regression equation showed that NT-proBNP was the independent risk factor of developing heart failure after neonatal asphyxia(OR=1.482,P<0.05).The area under ROC curve for heart failure in asphyxia neonates diagnosed by NT-proBNP was 0.952,95%CI 0.908-0.995(P<0.05). When the cut off value was (13 181 ng/L, the sensitivity of diagnosis was 90.20% and the specificity was 100.00%. Three-element linear regression analysis showed that LDH1, and cTnI had influence on NT-proBNP level, and the regression equation was NT-proBNP=-403.29+2.20×LDH1+271.04×cTnI.
Conclusion：Plasma NT-proBNP has some value in the diagnosis of heart failure after neonatal asphyxia, which is of great significance in early detection of heart failure and guiding the treatment.

Key words: Neonatal asphyxia, NT-proBNP, Heart failure, Diagnostic value