喜炎平注射液对腺病毒感染Hep-2细胞Bcl-2/Bax蛋白表达的影响

doi:10.3969/j.issn.1674-3865.2017.02.002

Abstract

Abstract:
Objective:To explore mechanism of antiviral mechanism of Xiyanping injection in vitroby invstigating influence of Xiyanping injection on expression of Bcl-2/Bax protein in adenovirus-infected Hep-2 cells.
Methods:The Hep-2 cells were infected with adenovirus, which were interfered with high, medium and low dose of Xiyanping injection and ribavirin. Then expressions of Bcl-2/Bax protein were measured by immunohistochemistry.
Results:The expressions of Bax protein in model group were significantly higher than normal groups（P<0.05）.The expression of Bax protein in all Xiyangping groups and ribavirin control group was lower than that of model group, and it was much lower in the high-dose Xiyanping group and ribavirin control group than in the model group(P<0.05). The expressions of Bal-2 protein in different groups had no significant difference（P>0.05）.
ConclusionXiyanping injection can kill ADV by suppressing the expressions of Bax protein. The high-dose Xiyanping injection is better than others.

Key words: Adenovirus, poptosis, Xiyanping injection

ZHANG Xiuying, WANG Xuefeng, WANG Siyuan, PING Jing. . Effect of Xiyanping injection on expression of Bcl-2/Bax protein in adenovirus-infected Hep-2 cells[J]. Chinese Pediatrics of Integrated Traditional and Western Medicine, 2017, 9(2): 96-99.

[1]	KANG Xiaojun，SUI Xiaodong，ZHUO Zhiqiang. Predictors of severe adenovirus pneumonia in children [J]. Chinese Pediatrics of Integrated Traditional and Western Medicine, 2020, 12(6): 534-.
[2]	. Present clinical application of Xiyanping injection in pediatric field [J]. Chinese Pediatrics of Integrated Traditional and Western Medicine, 2020, 12(1): 12-16.
[3]	CHEN Guangyuan. Effect of Xiyanping injection on intestinal mucosal barrier and myocardial enzyme spectrum level in children with rotavirus diarrhea [J]. Chinese Pediatrics of Integrated Traditional and Western Medicine, 2019, 11(5): 429-431.
[4]	MA Mingxing,WANG Xuefeng,ZHANG Xiuying,LI Linfeng,JIANG Junshuang,SONG Lichao. Xiyanping injection in the treatment of respiratory syncytial virus pneumonia in children Meta-analysis of effectiveness and safety [J]. Chinese Pediatrics of Integrated Traditional and Western Medicine, 2019, 11(4): 301-307.
[5]	WANG Shengzhi, CHEN Simin，LIU Yingnan，ZHENG Yan. Effects of Yiqi Jiedu Huayu Xiao Fufang and its single drug on proliferation and apoptosis of glomerular mesangial cells in rats [J]. Chinese Pediatrics of Integrated Traditional and Western Medicine, 2019, 11(3): 202-205.
[6]	HU Fengyang. Clinical observation on Xiyanping injection in the treatment of children with viral encephalitis [J]. Chinese Pediatrics of Integrated Traditional and Western Medicine, 2018, 10(5): 439-441.
[7]	LEI Xunming. Effects of ginseng Rg1 on hippocampal neuronal apoptosis and learning ability of neonatal rats with hypoxic-ischemic brain damage [J]. Chinese Pediatrics of Integrated Traditional and Western Medicine, 2018, 10(4): 277-279.
[8]	ZHU Benhui, LI Yuxia, XIE He. Clinical observation on Xiyangping injection in treatment of children with influenza [J]. Chinese Pediatrics of Integrated Traditional and Western Medicine, 2018, 10(3): 259-261.
[9]	SUN Honghua. Assistance of Xiyanping injection in improving immunological function of children with mycoplasma pneumonia [J]. Chinese Pediatrics of Integrated Traditional and Western Medicine, 2018, 10(2): 133-136.
[10]	RONG Ping，ZHAO Wei，ZHANG Xilian，WANG Wei，ZHANG Xuerong，MA Rong. Impact of Rongchang capsule on hippocampal neuron morphology and survival status in magnesium-free epilepsy cell model [J]. Chinese Pediatrics of Integrated Traditional and Western Medicine, 2018, 10(1): 1-5.
[11]	ZHANG Yunjuan，GOU Hongping，NIU Shaomin，DONG Xiangyu. Effect of different dose of astragalus injection on the Caspase-3 activity of mice with viral myocarditis [J]. Chinese Pediatrics of Integrated Traditional and Western Medicine, 2017, 9(4): 283-286.
[12]	PAN Fengqi,XU Hao. Efficacy of Xiyanping injection in assisting the treatment with azithromycin for chlamydia pneumonia in children [J]. Chinese Pediatrics of Integrated Traditional and Western Medicine, 2017, 9(4): 298-300.
[13]	ZHU Lili. Analysis of curative effect of Xiyanping injection in the treatment of children with acute upper respiratory tract infection [J]. Chinese Pediatrics of Integrated Traditional and Western Medicine, 2016, 8(5): 503-505.
[14]	WANG Liqiang,TAN Chunying. Effect of Xiyanping injection combined with budesonide suspension inhalation on neonatal bronchopneumonia in children [J]. Chinese Pediatrics of Integrated Traditional and Western Medicine, 2016, 8(5): 533-535.
[15]	HUANG Liang，WU Xia，JIANG Huiying. Clinical features and epidemiological analysis of adenovirus infection in children with diarrhea [J]. Chinese Pediatrics of Integrated Traditional and Western Medicine, 2016, 8(3): 348-350.

Effect of Xiyanping injection on expression of Bcl-2/Bax protein in adenovirus-infected Hep-2 cells

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics

Comments