Abstract:
Objective
To observe the clinical efficacy of Xiyanping injection in assisting the treatment for chlamydia pneumonia in children.
Methods
A total of 89 children with chlamydia pneumonia were included as the subjects and were randomly assigned to observation group(45 children) and control group(44 children). Children in both groups received intravenous infusion of azithromycin for 3 days, followed by a 4-day stop as a course, for two consecutive courses. Children in the observation group were also given Xiyanping injection 0.2 mL/(kg·d) via intravenous infusion for 10 days. The fever clearance time, effect on cough and side effects were observed between the two groups.
Results
There were 8 cases whose follow-up was lost because of bad compliance, so finally 81 children completed the treatment plan and follow-up in the two groups, 39 in the control group and 42 in the observation group. In the observation group, fever process was (3.28±1.52)days. The effective rate in treating cough was 59.5%(25/42), 73.8%(31/42) and 90.5%(38/42) at 3, 7 and 14 days of treatment, respectively. The incidence of side effects of azithromycin was 9.5%(4/42). In the control group, fever process was (4.89±1.46) days. The effective rate in treating cough was 20.5%(8/39), 41.0%(16/39) and 66.7%(26/39) at 3, 7 and 14 days of treatment, respectively. The incidence of side effects of azithromycin was 28.2%(11/39). Significant differences were shown between the two groups(P<0.05). Before and after treatment, there was no abnormal change in routine blood and urine test, liver function or myocardial enzymes.
Conclusion
Xiyanping injection in adjuvant treatment of chlamydia pneumonia in children can rapidly relieve fever and cough, and reduce the incidence of side effects of gastrointestinal irritation caused by azithromycin.

Key words: Chlamydia pneumonia, Xiyanping injection, Azithromycin, Children