Abstract:
Objective
To investigate the clinical efficacy of Chinese medicine "Xingbi gel nasal drops" in treating allergic rhinitis(AR) in children and find out the correlation of IL-4, IL-13, and TSLP with AR, and in turn to reveal the mechanism of the onset of AR and the mechanism of Chinese traditional medicine "Xingbigel nasal drops" for treating allergic rhinitis in children.
Methods
Totally 60 children diagnosed with allergic rhinitis were included in the study, and divided into two groups: the group of traditional Chinese medicine(30 children) and that of western medicine(30 children).Ten healthy volunteer children were included as the control group. The TCM group was treated with Xingbi gel and the western group was treated with budesonide nasal spray, the treatment lasting for 2 courses, with 2 weeks in each course. Before and after treatment, the level of serum IL-4, IL-13 and TSLP was determined, the symptom score and visual analog scale were evaluated, and the clinical effect was observed.
Results
After 4 weeks of treatment, the difference in total effective rate was of no statistical significance between the two treatment groups(P>0.05). After 4 weeks of treatment , the level of IL-4, IL-13 and TSLP in the two treatment groups was significantly lower than before treatment(P<0.05); their levels were higher than the healthy control group, and the difference was statistically significant(P<0.05). The level of IL-4 and IL-13 in TCM group was significantly lower than that in western group(P<0.05). There was no statistical difference in the TSLP level between the TCM group and western group(P>0.05). After 4 weeks of treatment, the total symptom score and visual analog scale score of TCM group were lower than before treatment, and there was statistical difference(P<0.05); the visual analog scale score was lower in the TCM group than that in the western group, and the difference was of statistical significance(P<0.05).
Conclusion
The Chinese medicine, Xingbi gel, down-regulates the level of IL-4，IL-13 and TSLP in children with allergic rhinitis and regulate the immune balance mechanism of the body, thus intervening allergic rhinitis, and improving the clinical symptoms.

Key words: Allergic rhinitis, Xingbi gel, Interleukin 4, Interleukin 13, Thymic stromal lymphopoietin, Children