Abstract:
Objective
To study the clinical effect of loratadine combined with montelukast on children with cough variant asthma.
Methods
From Jan. 2015 to Jan. 2016, a total of 80 children with cough variant asthma hospitalized  in our hospital for treatment were taken as the clinical research objects, and they were randomly divided into control group(40 cases）and treatment group(40 cases）. Both groups were treated with montelukast chewable tablets,5 mg per time, once a day for 3 months; besides, the treatment group was additionally given loratadine 5 mg before bedtime for continuous 2 months. The clinical efficacy and improvement of physical signs and symptoms in the two groups were compared after stopping the treatment for 2 months.
Results
The total effective rate in the treatment group was 95.0%, which was significantly higher than that in the control group(77.5%,P<0.05）;the disappearance time of cough and expectoration, and asthma duration in the treatment group were all shorter than those in the control group（P<0.05）.
Conclusion
Loratadine combined with montelukast has significant effect in the treatment of children with cough variant asthma.

Key words: Cough variant asthma, Loratadine, Montelukast, Children