先天性巨结肠患儿结肠组织钾离子通道蛋白表达的变化

doi:10.3969/j.issn.1674-3865.2017.05.015

Abstract

Abstract:
Objective
To observe the changes of potassium channel protein expression in colon tissue of children with congenital megacolon.
Methods
Forty patients with congenital megacolon treated in Hunan Children's Hospital from October 2010 to October 2016 were enrolled as the observation group. The 40 patients with intussusception were selected as the control group. The expression of potassium channel protein in colon tissue was measured by immunohistochemistry.
Results
The positive rate of HERG1 potassium channel protein expression and Kv3.4 potassium channel protein was 85.0%(34/40) and 90.0%(36/40) respectively, which were significantly higher than those of control group［0%, 10.0% (4/40)］, the difference being statistically significant(P<0.05).
Conclusion
The potassium channel protein of colonic tissue in children with congenital megacolon is characterized by high expression, which may be one important pathogenesis of congenital megacolon.

Key words: Congenital megacolon, Colon tissue, Potassium channel, Children

HUANG Zhao，LI Ming，ZHOU Yuxiang，XIAO Yaling. Changes of potassium channel protein expression in colon tissue of children with congenital megacolon[J]. Chinese Pediatrics of Integrated Traditional and Western Medicine, 2017, 9(5): 413-415.

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Changes of potassium channel protein expression in colon tissue of children with congenital megacolon

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