Abstract:
Objective
To observe the effect of continuous infusion of remifentanil at different doses on spontaneous breathing of children under sevoflurane anesthesia.
Methods
A total of 126 cases of inguinal hernia repair in Hunan Children's Hospital from January 2016 to December were selected as the research subjects. They were divided into high-dose group and low-dose group by random number table, each with 63 cases. The children inhaled 8% sevoflurane, and the concentration of sevoflurane drugs was lowered when patients were in deep anesthesia; the right type of LM was chosen and the children was given 1 μg/kg intravenous infusion of remifentanil(>1 min) when the concentration of seven halothane of expiratory end was 1.3%. After that, the high-dose group was treated with 0.08 g/kg remifentanil by continuous infusion, and the low-dose group was treated with 0.04 g/kg remifentanil by continuous infusion. The RR,MV,VT and PCO2 at T1(after LM placement), T2(after intravenous transfusion of remifentanil), T3(10 min after continuous infusion), T4(15 min after continuous infusion) and T5(after LM removal) of the two groups were observed.
Results
The RR and VT of the high-dose group were significantly lower than those of the low-dose group in the period of T3 to T5, the difference being statistically significant(P<0.05). In the T3 and T4 periods, the PCO2 in the high-dose group being significantly higher than that in the low-dose group, the difference being statistically significant(P<0.05). There was no significant difference in VT between the two groups at different time points(P>0.05).
Conclusion
Sevoflurane combined with 0.04 g/kg remifentanil can effectively improve the ability of spontaneous breathing of children, and meet the clinical needs. It is worthy of clinical application.

Key words: Anaesthesia, Remifentanil, Sevoflurane, Continuous infusion, Children