Abstract:
Objective
To observe and analyze the clinical efficacy of different doses of gamma globulin in the treatment of children with immune thrombocytopenia.
Methods
A total of 94 children with immune thrombocytopenia who were treated in our hospital from November 2014 to December 2016 were randomly divided into low-dose group(n＝47) and conventional-dose group(n＝47). Both groups of children were treated with dexamethasone. The low-dose group was treated with 200 mg/(kg·d) gamma globulin. The conventional-dose group was treated with 400 mg/(kg·d) gamma globulin,once a week for one month. Observe the following items: clinical effect, duration of platelet increase, time of platelet rising to normal level, peak time of platelet, coagulating time of platelet, hospital stay, treatment expense, WBC count, hemoglobin, platelet count and the incidence of adverse reactions.
Results
There was no statistical difference in the total effective rate between the two groups(P>0.05). There was no statistical difference in duration of platelet increase, time of platelet rising to normal level, coagulating time of platelet or hospital stay(P>0.05) between the two groups. There was no statistical difference in WBC count or hemoglobin(P>0.05) between the two groups(P>0.05). After treatment, the platelet count was significantly higher in low-dose group than in conventional-dose group and there was statistical difference(P<0.05). The peak time of platelet was significantly shorter in low-dose group than in conventional-dose group with statistical difference(P<0.05). The treatment expense was also less in the conventional-dose group and there was statistical difference(P<0.05). There was no statistical difference in the incidence of adverse reactions between the two groups(P>0.05).
Conclusion
The effect and safety of these two doses of gamma globulin is similar in the treatment of children with immune thrombocytopenia; however, the low-dose treatment results in shorter peak time of platelet with less expense, so it is worthy of clinical application.

Key words: Immune thrombocytopenia, Gamma globulin, Children