外周血淋巴细胞亚群检测对儿童亚急性坏死性淋巴结炎的诊疗意义

doi:10.3969/j.issn.1674-3865.2018.02.006

Abstract

Abstract:
objective
To investigate the significance of peripheral blood lymphocyte subsets detection in the diagnosis and treatment of children with subacute necrotizing lymphadenitis(CSNL).
Methods
The percentage of lymphocyte subsets in peripheral blood of 51 children with CSNL(CSNL group) and 30 healthy children(control group) was detected by flow cytometry(FCM), and the treatment results of CSNL were observed.
Results
In the 51 cases of CSNL,38 were cured,12 improved and 1 failed. Before treatment, the percentage of CD3+,CD4+ and CD19+ of lymphocyte subsets and CD4+/CD8+ of CSNL group were significantly lower than control group(P<0.05).The percentage of CD3+,CD4+ and CD19+ of lymphocyte subsets and CD4+/CD8+ of the 51 children with CSNL were significantly higher during and after treatment than before treatment(P<0.05),and the index after the treatment was higher than that during treatment(P<0.05).
Conclusion
The CD3+,CD4+ and CD19+ of peripheral blood lymphocyte subsets and CD4+/CD8+ can be used as important indicators for clinical diagnosis and treatment of CSNL.

Key words: CSNL, Lymphocyte subsets, CD3+\CD4+, CD4+, CD8+, CD19+, Child

ZHU Linchao，ZHANG Shufeng，WANG Xuhui，WANG Lin，WANG Xiaohui，SUN Ying. Significance of peripheral blood lymphocyte subsets detection in the diagnosis and treatment of children with subacute necrotizing lymphadenitis[J]. Chinese Pediatrics of Integrated Traditional and Western Medicine, 2018, 10(2): 109-113.

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Significance of peripheral blood lymphocyte subsets detection in the diagnosis and treatment of children with subacute necrotizing lymphadenitis

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