Abstract:
objective
To investigate the application and safety of sevoflurane combined with remifentanil in the surgery for children receiving adenotosillectomy in ENT Department.
Methods
Totally 120 cases of children undergoing adenotosillectomy from May 2016 to October in Department of ENT, Kaifeng Central Hospital were chosen and randomly divided into observation group and control group, 60 cases in each group; the observation group were treated with sevoflurane combined with remifentanil anesthesia, and the control group were treated with propofol with remifentanil anesthesia; the records were compared between the two groups of children concerning heart rate，systolic and diastolic blood pressure changes at different time, recovery of anesthesia, and incidence of adverse reactions.
Results
There was no significant difference in heart rate, systolic or diastolic blood pressure before anesthesia and 5 minutes after extubation in two groups(P>0.05). The heart rate, systolic and diastolic blood pressure were significantly higher in the observation group than in the control group 5 minutes after intubation and 5 minutes after the operation, the difference being statistically significant(P<0.05).After surgery the recovery time of spontaneous breathing and subjective consciousness and tracheal extubation time were significantly shorter in the observation group, which was statistically significant(P<0.05). No respiratory depression，arrhythmia，larygospasm or laryngeal edema were found in both groups. The incidence of adverse reactions(restlessness, crying, nausea and vomiting) in the observation group was significantly lower than that in the control group, the difference being statistically significant(P<0.05).
Conclusion
In the process of adenotosillectomy for children in department of ENT, the use of sevoglurane combined with remifentanil anesthesia has good effects of anesthesia, with stable hemodynamics, quick recovery and low incidence of adverse reactions, and is safer.

Key words: Anesthesia, Sevoflurane, Remifentanil, Adenotosillectomy, Children