Abstract:
Objective
To observe the clinical effect of Saccharomyces boulardii and compound clove appetizing paste in the treatment of gastrointestinal symptoms of hand-foot-mouth disease.
Methods
Totally 220 children with hand-foot-mouth disease hospitalized in Dalian Children's Hospital Affiliated to Dalian Medical University from June to September in 2016 were selected as the subjects. They were randomly divided into the observation group and the control group, 110 cases in each group. Both groups were treated with antiviral or combined antibiotics. The observation group was also treated with Saccharomyces boulardii and compound clove appetizing paste for 6 days. The incidence of gastrointestinal symptoms and adverse reactions were compared between the two groups.
Results:Twelve cases of the control group and 14 cases of the observation group had severe complications of hand-foot-mouth disease(HFMD) and withdrew from the study. The incidence of inappetence， nausea, vomiting， abdominal pain， diarrhea， abdominal distension and dry stool was 65.3%(64/98）， 42.9%(42/98）， 46.9%(46/98）， 34.7%(34/98）， 36.7%(36/98）and 22.4%(22/98）respectively in control group, which was higher than that of the observation group［(29.2%,28/96），(18.8%,18/96），(12.5%,12/96）， (14.6%,14/96），(13.5%,13/96） and (8.3%,8/96）］.The difference was statistically significant(P＜0.05).In the observation group, only 6 cases had redness of skin around the navel due to the compound clove appetizing paste, no rash or blister. Skin redness was relieved within 48 hours of termination of drug use, and no other adverse reactions occurred.
Conclusion:Saccharomyces boulardii and compound clove appetizing paste can effectively reduce the incidence of gastrointestinal symptoms in children with hand-foot-mouth disease. The therapy is worth clinically recommending and applying.

Key words: Hand-foot-mouth disease, Saccharomyces boulardii, Compound clove appetizing paste, Children