Abstract:
Objective
To detect the expression of PTX3 in plasma and urine of children with HSP and HSPN, and to explore its clinical significance.
Methods
A total of 50 HSP children were selected, who were treated in the First Affiliated Hospital of Xinxiang Medical College from Mar. 2016 to Sep. 2017, and they were divided into two groups based on whether kidney was involved: HSP group(32 cases) and HSPN group(18 cases). Twenty healthy children receiving physical examination during the same period were included as the control group. The expression level of PTX3 in plasma and urine was determined in the 3 groups; the expression level of PTX3 of HSP group and HSPN group in the plasma and urine at acute stage and recovery stage was also determined.
Results
(1)The expression level of PTX3 in plasma and urine was significantly higher in HSP and HSPN group than in control group(P<0.05); the level was significantly higher in HSPN group than in HSP group(P<0.05).(2)The PTX3 expression level of HSP and HSPN group was significantly lower at recovery stage than at the acute stage(P<0.05).
Conclusion
The detection of the expressions of PTX3 not only reflect the active state of HSP disease, but also may be a new detection index of renal damage in children with HSP.

Key words: Henoch-Schonlein purpura, Henoch-Schonlein purpura nephritis, Pentraxin 3, Children