Abstract:
Objective
To analyze the related factors for recurrence acute lymphoblastic leukemia(ALL) in child patients after treatment with 2016 regimen of South China Children's Acute Lymphocytic Leukemia Treatment Cooperative Group(SCCLG-2016).
Methods
Totally 364 child patients with ALL who underwent SCCLG2016 regimen in Department of Hematology and Oncology of Shenzhen Children's Hospital were selected for the study. The treatment results of 364 patients who underwent SCCLG-2016 regimen were analyzed, and the recurrence and related pathological data were followed up. Logistics regression analysis was used to analyze the independent risk factors affecting recurrence after treatment.
Results
The recurrence rate was 18.68% (68/364) in 364 children patients with ALL, and there were significant differences in the age, white blood cell count, fusion gene positive rate, minimal residual disease and risk grading between recurrence group and no-recurrence group(P<0.05). The age ≥10 years old, white blood cell count ≥100×109/L and positive BCR/ABL gene and high risk grade were independent risk factors for recurrence in child patients with ALL after treatment.
ConclusionAge ≥10 years old, white blood cell count ≥100×109/L, positive fusion gene and high risk grade are independent risk factors for recurrence in child patients with ALL after SCCLG-2016 regimen. Paying close attention to the above factors during treatment is helpful to identify the patients with higher probability of recurrence so as to give early intervention.

Key words: Acute lymphoblastic leukemia, SCCLG-2016 regimen, Recurrence, Children