Abstract:
Objective
To study the level of S100B and NSE in cerebrospinal fluid of pneumonia mycoplasma pneumonia（MPP）complicated with central nervous system damage in children.
Methods
Totally 35 cases of MPP complicated with central nervous system damage were chosen as observation group, and 40 MPP children were included as control group; all the children were treated in Pediatric Department of Yuebei People's Hospital in Shaoguan from Jan. 2017 to Feb. 2019. The clinical manifestations on admission and the related auxiliary examinations were compared between the two groups. Examination of S100B and NSE in cerebral fluid was completed within 3 days of admission in MPP children with central nervous system damage at acute stage, and re-examination was carried out after 2 weeks of treatment. Based on the prognosis, the difference in S100B and NSE in cerebral fluid before and after treatment was compared between the cured children and the uncured children.
Results
In the observation group, there were 26 cases (74.3%) of high fever, whose incidence was significantly higher than that in control group (47.5%, 19 cases) (P<0.05). There were 35 cases (100%) of elevated C-reactive protein in observation group, significantly more than those in control group (28 cases, 70.0%) (P<0.05). After 14 days of treatment, 28 children (80.0%) were cured, while 7 (20.0%) still had obvious nervous symptoms, including 5 cases of disturbance of consciousness and 2 cases of abnormality in mental behavior and intelligence. There was no difference in NSE within 3 days of admission at acute stage between the cured children and uncured children (P<0.05). After 14 days of treatment, the NSE in uncured children was significantly higher than that in cured children (P<0.05); S100B in uncured children was significantly higher than that in cured children both within 3 days of admission at acute stage and at 14 days after treatment (P<0.05).
Conclusion
The content of NSE and S100B in cerebral fluid is related to the disease severity of MPP children with central nervous system damage, and S100B is obviously abnormal at the early stage.

Key words: Mycoplasma pneumoniae pneumonia, Central nervous system, S100B, NSE, Child