Abstract: Objective To explore the repetitive transcranial magnetic stimulation(rTMS) combined rehabilitation training，including behaviour analysis therapy，social training，speech therapy，and sensory integration training，on the stereotyped behavior of children with autism spectrum disorder(ASD). Methods Sixty ASD children，who were hospitalized and treated in Henan Provincial Hospital from Sep. 2017 to Sep. 2019, were randomly divided into rTMS group and control group， with 30 cases in each group. The two groups of children received the behavior analysis therapy，speech therapy and sensory integration training. The rTMS group was given additional rTMS therapy(rTMS was performed before rehabilitation training). The course of treatment was 12 weeks. Before and after treatment，the childhood autism rating scale(CARS) and autism behavior check scale(ABC) were used to evaluate. The total improvement rate of core symptoms was compared between the two groups. Results After 12 weeks of treatment，the CARS and ABC scores of the two groups were significantly lower than those before treatment(P<0.05). The CARS and ABC scores in the rTMS group were significantly lower than those in the control group（P<0.05）， and the overall improvement rate of core symptoms in rTMS group(100%,30/30) was significantly higher than that in the control group (86.7%,26/30)(P<0.05). Conclusion The rTMS combined with rehabilitation training and conventional rehabilitation training has certain promoting effects on core symptoms of children with ASD. The efficacy of rTMS combined rehabilitation training is significantly better than conventional rehabilitation training.

Key words: Autism spectrum disorder, Repetitive transcranial magnetic stimulation, Core symptoms, Children