Abstract: Objective：To analyze the serum levels of bone metabolism indexes in early neonates.Methods：A total of 121 early neonates who were admitted to the neonatal department of our hospital from July 2018 to December 2019 were included. The concentration of serum indexes of bone metabolism was determined, including ALP, PINP, β-CTX, Ca, P, 25-(OH)D, PTH and CT, and the serum levels were analyzed.Results：(1) The serum PINP levels were all more than 1 200.00 μg/L, and 111 cases (91.74%) had lack or deficiency of vitamin D. (2) The level of PTH was higher in preterm infants than in term infants, while CT level was lower, and the difference was statistically significant(P<0.05). There was no difference in the other bone metabolism indexes between the preterm infants and term infants(P>0.05). (3) There was no correlation between serum levels of bone metabolism indexes and maternal age or gestational age. The β-CTX was negatively correlated with head circumference; Ca was positively correlated with body weight and head circumference; PTH was negatively correlated with body weight and body length; CT was positively correlated with body weight.Conclusion：(1)The incidence of lack of vitamin D or deficiency is high, and it is necessary to strengthen the regular supplementation of vitamin D in pregnant mothers. (2)The serum levels of PTH and CT in newborns are related to gestational age. The serum level of PTH in the preterm infants was higher than that in term infants, while the CT level was lower. (3)Serum levels of newborn bone metabolism indexes are related to body weight, head circumference, and length.

Key words: Bone metabolism marker, 25-hydroxycholesterol, Parathyroid hormone, Calcitonin, Newborn