Abstract: Objective To explore the related risk factors of influenza complicated with pneumonia in children, in order to achieve early identification and perform  correct treatment.Methods A total of 446 cases of influenza in children hospitalized in Guangzhou Eighth People′s Hospital from April 2016 to March 2019 were retrospectively analyzed. They were divided into pneumonia group(n=212) and non-pneumonia group(n=234) according to whether they were complicated with pneumonia or not. Through consulting the relevant clinical data of the studied cases the research information was collected, including gender, age, fever, history of wheezing, chest imaging, blood routine, hsCRP, PCT, myocardial enzyme spectrum and medication. The factors which had statistical significance according to single-factor comparison were included in the multivariate Logistic regression analysis.Results The single factor comparison of clinical data between the two groups showed that there were significant differences in age＜3 years old, fever＞4 days, WBC＜3×109/L, hsCRP＞20 mg/L, PCT＞2 μg/L and application of oseltamivir 48 hours after onset(P<0.05).Further multivariate Logistic regression analysis showed that age＜3 years old, hsCRP＞20 mg/L and application of oseltamivir 48 hours after onset were independent risk factors of influenza complicated with pneumonia in children.Conclusion For children with influenza with CRP>20 mg/L who have poor response to treatment，chest X-ray should be taken in time to exclude pneumonia. The children under 3 years should be given oseltamivir within 48 hours of onset, which is of great significance in reducing pneumonia and improving prognosis.

Key words:

Influenza, Pneumonia, Risk factors, Children