Abstract:

Objective To investigate the effect of the combined detection of lactate dehydrogenase(LDH), procalcitonin(PCT) and adenosine dehydrogenase(ADA) in evaluating different types of central nervous system infections in children.Methods A total of 92 children with central nervous system infection admitted to our hospital from March 2019 to March 2021 were selected and divided into bacteria group(52 cases) and virus group(40 cases) according to different types. In the same period, 60 children with migraine without central nervous system infection were selected as the control group. Compare the levels of LDH, PCT and ADA among the three groups, find out the best cut-off values of bacterial meningitis and viral meningitis in the above-mentioned cerebrospinal fluid indexes based on the receiver operating characteristic(ROC) curve, and then analyze the area under the ROC curve(AUC) under separate and combined detection of LDH, PCT and ADA. Results The levels of LDH, PCT and ADA in the bacteria group were higher than those in the virus group, and the difference was statistically significant(P<0.05); the levels of LDH, PCT and ADA in the virus group were higher than those in the control group, and the difference was statistically significant(P<0.05). LDH, PCT, and ADA were used to complete single and multiple tests on children in the bacteria and virus groups. It was found that the best cut-off values of the above indicators when tested separately were 25.95 U/L,1.89 μg/L and 0.87 U/L, respectively.The AUC of LDH, PCT and ADA for combined diagnosis of children with bacterial meningitis was significantly greater than the AUC of the individual diagnosis, and the difference was statistically significant(P<0.05).Conclusion For the diagnosis of bacterial meningitis and viral meningitis, the combined detection of LDH, PCT and ADA in the tandem mode has higher application value.

Key words:

Central nervous system infection, Cerebrospinal fluid, Combined detection, Different types, Children