Abstract:
ObjectiveTo observe the protective effect of Xin Yan Ning Granule on myocardial cells infested with Coxsackie virus B3 (CVB3m) in the vira myocarditis myicardial cell model.MethodsViral myocarditis myocardial cell model was made by in vitro primary cultured myocardial cells in neonatal SD rat, infected with CVB3m, given Xin Yan Ning Granules respectively to determine of the maximum toxic dose (TD0), cell lesions (CPF), median lethal dose (TCID50), and the protection effect on myocardial cells.ResultsThe rate of different concentrations of Xin Yan Ning Granule on myocardial cell protection had a significant difference (P＜ 0.05);the protection rate of 4TD0, TD0, 1/2TD0, 1/4TD0 on myocardial cells was significantly higher than that of the 1/8TD0, the difference being statistically significant (P＜0.05);the protection rate of 4TD0 and 1/4TD0 on myocardial cells had a significant statistical difference from that of 1/32TD0(P＜0.05).ConclusionsXin Yan Ning Granule has a significant protective effect on myocardial cells with CVB3 infection.

Key words: Xin Yan Ning Granule, Coxsackie B virus, myocardial cells