Abstract: Objective：To investigate the effects of tonifying Qi,nourishing Yin,clearing and promoting blood circulation on MCNS rats.Methods：The MCNS model rats were induced by ADR venoclysis through caudal vein.Different treatment was given to each group by ig administration for 4 weeks.We observed the amount of protein in urine,determined the levels of Alb,TC,TG,BUN,Scr and NO in serum and the NO in kidney tissue,and observed morphologic change in kidneys.Results：Compared with the normal group,the levels of NO in rats serum and kidney tissue in the model group were increased（P＜0.05～0.01）.tonifying Qi，nourishing Yin,clearing and promoting blood circulation could decrease the amount of protein in urine and the levels of TC,TG,BUN,Scr and NO in serum,decrease the NO in kidney tissue（P＜0.05～0.01）,and repair injured foot process of glomerule epithelial cell.Conclusion：tonifying Qi，nourishing Yin,clearing and promoting blood circulation have obvious protective effect on MCNS rats,decrease the NO in serum and kidney tissue and prevent the further development of MCNS.

Key words: Minimal change nephrotic syndrome (MCNS), Nitric oxide(NO)；tonifying Qi and nourishing Yin clearing and promoting blood circulation, Chinese herbs/treatment application；Animal,experiment