ISSN 1674-3865  CN 21-1569/R
主管:国家卫生和计划生育委员会
主办:中国医师协会
   辽宁省基础医学研究所
   辽宁中医药大学附属医院

Chinese Pediatrics of Integrated Traditional and Western Medicine ›› 2016, Vol. 8 ›› Issue (1): 36-38.doi: 10.3969/j.issn.1674-3865.2016.01.014

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Feasibility analysis of antihepatitis B immunoglobulin combined with hepatitis B vaccine in blocking the transmission of hepatitis B virus infection between father and infant

MA Yanni   

  1. Department of Infectious Diseases,People's Central Hospital in Zhanjiang,Zhanjiang 524038,China
  • Published:2016-02-25 Online:2018-11-19

Abstract:
Objective:To observe the clinical effect of anti-hepatitis B immunoglobulin combined with hepatitis B vaccine in blocking the transmission of hepatitis B virus infection between father and infant.
Methods:Totally 68 pairs of pregnant women and their spouses in People's Central Hospital in Zhanjiang from January 2012 to May 2015 were selected as the subjects of study and were randomly divided into the observation group and the control group,34 pairs in each group,among whom women were not infected with hepatitis B virus but their spouses were hepatitis B patients.The newborns in the control group were injected with hepatitis B vaccine while the newborns in the observation group were injected antihepatitis B immunoglobulin on the basis of the treatment for the control group.The birth weight,Apgar scores,the levels of alanine aminotransferase(ALT) and the test results of hepatitis B virus(HBV) of the newborns in two groups were observed.
Results:The differences of the birth weight,Apgar scores,and the levels of ALT of the newborns in the two groups had no statistical significance(P>0.05).The positive rate of HBsAg of the newborns in the observation group was 5.88%(2/34),which was lower than 23.53%(8/34) of the control group,and the difference had statistical significance(P<0.05).The positive rate of HBsAb of the newborns in the observation was 32.35%(11/34),which was higher than 11.76%(4/34) of the control group,and the difference was statistically significant(P<0.05).
Conclusion:The application of antihepatitis B immunoglobulin combined with hepatitis B vaccine to newborns can effectively block the transmission of hepatitis B virus infection,and significantly reduce the rate of neonatal infection.

Key words: Hepatitis B, Immunoglobulin, Transmission between father and infant, Children