Abstract: Objective：To analyze the epidemiology and drug resistance in 200 children with mycoplasma pneumonia and to provide reference for clinical treatment.Methods：Throat swabs were collected from 652 children with respiratory infection in out-patient department in our hospital. The swabs were cultured to detect MP. The MP infection was recorded according to seasons, ages and gender. The drug resistance to multiple antibiotics was detected.Results：MP culture showed that the positive rate was 30.67%;the infection rates in different seasons had differences, and the infection rate was the lowest in winter(15.00%), which was significantly lower than that in other seasons(P<0.05),and it was the highest in fall(38.50%);the infection rate in male children was slightly lower than the female patients(30.02% vs 31.80%,P>0.05);the infection rates in different age groups were significantly different(P<0.05):0-1-year-old group was higher than the 6-14-year-old group(P<0.008 3). Susceptibility test showed that drug resistance rates were significantly different to different antibiotics(P<0.05).ERY and ROX resistance rates were significantly higher than AZI(P<0.05).Conclusion：MP infection in children with respiratory tract infection has high proportion, which is age-related; it doesn't often occur in winter, and in the clinical treatment MP throat swab culture and drug sensitivity testing are required to guide the clinical administration.

Key words: Mycoplasma pneumoniae, Epidemiological, Drug resistance, Children