Abstract:
Objective
To study the risk factors of severe hand-foot-mouth diseased(HFMD) complicated with heart and lung function failure in children and the therapeutic effect.
Methods
A total of 108 HFMD children were treated in Kaifeng Children's Hospital from May 2015 to May 2016,and they were randomly divided into two groups: two-drug group and three-drug group, with 54 children in each. There were 45 cases with heart and lung failure and 9 cases without heart and lung failure in each group. The treatment of two-drug or three-drug was performed according to the disease condition. Xiyanping injection and gamma globulin were used in the two-drug treatment group; Xiyanping injection, gamma globulin and mannitol or milrinone or dobutamine were used in the three-drug group. Analyze the risk factors of the HFMD children complicated with heart and lung failure; observe the clinical effect, complications, mortality, average hospital stay, recovery time of myocardial enzyme, and the time to withdraw respirator.
Results
The total effective rate in three-drug group was 100.0%(54/54),significantly higher than the 83.3%(45/54) of the two-drug group, the difference being statistical(P<0.05).The incidence rate of complications and mortality in three-drug group was significantly lower than that in two-drug group(P<0.05).The average hospital stay, recovery time of myocardial enzyme and the time to withdraw respirator in three-drug group were all shorter than those in two-drug group(P<0.05). The hemodynamic change, EV71 infection, polypnea, disorders of consciousness and increase of troponin were of a higher proportion in children complicated with heart-lung failure than in those without, and the difference was of statistical significance(P<0.05).Multi-factor Logistic regression analysis showed that hemodynamic change, EV71 infection and polypnea were the independent risk factors.
Conclusion
The heart-lung function failure in Children with severe HFMD is mainly related to hemodynamic change, EV71 infection and polypnea. The three-drug treatment can achieve great effect, which lengthens the survival time of patients, improves the prognosis and meets the treatment demand. Therefore it should be popularized.

Key words: Hand-foot-mouth disease, Severe, Heart and lung function failure, Risk factors, Treatment effect, Child