Abstract: Objective:To investigate and analyze the clinical distribution and drug resistance of carbapenem-resistant Klebsiella pneumoniae(CRKP) in children.
Methods:All kinds of submitted samples of children hospitalized in the hospital from December 2015 to December 2018 were collected. Isolation and culture of CRKP and bacterial identification were performed on the submitted samples. The K-B method and drug sensitivity card were used to test the sensitivity of the isolated CRKP strains. The distribution characteristics of CRKP infection in children were analyzed, and the resistance to commonly used antibacterial drugs was analyzed.
Results:A total of 156 strains of CRKP were isolated, including 149 strains detected by Carba NP test, with a positive rate of 95.51%. The main specimens were sputum and urine specimens, accounting for 51.28% and 16.67%, respectively. The main departments from which CRKP strain specimens came included the Neonatology Department(29.49%), the Respiratory Department (25.64%) and the ICU (14.10%). Among the other 16 antibiotics commonly used in the clinic, the resistance rates of CRKP to cephalosporins, penicillins and quinolone antibiotics were higher than 90%. The resistance to aminoglycoside, tetracyclines and sulfonamides was relatively low.
Conclusion:CRKP infection is widespread in children, especially in the Neonatology Department. In addition, the resistance of carbapenem-resistant Klebsiella pneumoniae is serious, and it has high resistance to most of the antibiotics. Therefore, it is necessary to choose antibiotics reasonably according to the results of drug sensitivity so as to effectively control infection.
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Key words: Klebsiella pneumoniae, Carbapenemresistant, Drug resistance, Children